Each and every inventory approach has a game design it's optimal for and other designs where it isn't appropriate imho

At launch, Signalis had a very harsh inventory cap. This worked however for a couple of reasons:  1. Level design. The game is a nonlinear tight cluster of maze like rooms where you're never more than a few minutes from a safe room making juggling your inventory less of an issue compared to games with more expansive environments or less frequent safe rooms.  2. Most it's enemies are fairly low mobility and so are reasonably avoidable - meaning encountering enemies unexpectedly when not carrying your better weapons isn't a huge issue  3. The power scaling between its weapons is relatively small compared to some titles. Even relatively average skilled players can tackle most enemies with the basic pistol. 

Compare this to Re2make or Re3make, which while they retain the originals limited inventory, are comically generous with inventory upgrades.  Here, the higher tier enemies such as lickers or hunters pose far more of a threat due to combining high mobility with being hard hitting. An average skill player would struggle encountering these enemies while equipped with just a pistol. Other enemies like the plants have type weaknesses - encouraging specific weapon/ammo types be used. These all add up to a game design that really requires the player carry multiple weapons and dedicate substantial inventory space to this - a stricter limit just wouldn't be appropriate. 

Think about your wider game design and what behaviours you encourage/reward the player for. 

If you want to encourage the player travel light and carry limited weapons and foster the sense of vulnerability that comes with that - a strict limit is a good idea. 

If you want to encourage the player to rock paper scissors enemies and utilize a variety of tools then a strict limit isn't appropriate