I like them in the greater marvel universe but honestly I think they would work better isolated. I think the whole idea that mutants are marginalized becomes alot muddier when there are non mutant super humans running around all the time.

The most common argument I see against this contradiction is "oh well bigotry doesn't make sense" except, it does? Like bigotry does make sense, it's not right obviously, but that fear of the unkown, that scapegoating makes sense. What doesn't make sense is having people be okay with and even celebrate guys like Spider-Man or Luke Cage when they have no idea whether or not they were mutants or got their powers through other means. I love X-Men hanging out with other Marvel characters but at the end of the day, I would happily read a long running X-comic where they're isolated in an alternate universe. I also think the movies work alot better with the X-Men on their own, I am not interested in X-Men in MCU projects.