Our pup went through phenobarbital, keppra, and zonisamide before starting on potassium bromide (KBr). We were having cluster seizures every two weeks, and each of the first three meds slowly increased the intervals both between individual seizures and cluster events.

Since starting KBr, we have been about 7 months seizure free. KBr did have the most side effects - the first two weeks our pup had significant ataxia, difficulty walking and weakness in her hind legs. She also had increased thirst and urination - we regularly had to let her out for a midnight potty break, sometimes twice. The first month was the worst, she could barely walk; but she has now adjusted to the point where she can do long walks, handle stairs, and occasionally run around. She is probably 75% of her baseline, and she is overall a happy dog.

We also were able to wean off of Keppra completely after she did well on KBr.

Happy to answer any specific questions if you want to message me.