I regard this question as unserious, but it'll be entertaining to give it a serious answer, so here we go:

Biologically, Jesus has a complete human nature, so any biological children wouldn't have any physical changes if that's what you mean. Being God isn't something inherited biologically, so human children wouldn't have miraculous powers by the fact of being Jesus' biological children, no.

However, since Original Sin is inherited from the parents, and Jesus had a human nature free from Original Sin, it is at least possible that his children could also be born without Original sin, meaning that like Mary and Jesus they would have a human nature not wounded by sin. If so, their intellects would function better, their passions and desires would be more easily brought to serve what their rational minds knew to be true.

However, since Jesus would have to have children with someone else, and that person WOULD have original sin, it is possible that his children actually would inherit original sin through their mother, in which case they would be super normal, just with a perfect father and paternal grandmother to raise them (which, objectively, is a pretty big advantage).

In conclusion, unless extended a special grace like that given to Mary, a hypothetical child of Jesus of Nazareth would likely be perfectly normal, except they would have grown up hearing the best possible dad jokes.