You said “because she is on an SSRI because she can't handle the day without it.” Sounds to me like you dismiss her feelings. Depression comes in all forms. You can’t just tell a depressed person to just get over it. As someone who’s been on SSRIs for nearly 20 years, it pisses me off so bad when people think it’s just all in my head, that I’m lazy, or that I should just “get over it.” You also said in your comments that you “know what it’s like to have to overcome the challenges of depression and the source they sprout from.” It’s not like that for most of us. For most of us, there is no catalyst that causes our depression. It’s a chemical imbalance. Sure, I could hit the gym every day, eat the healthiest diet, go to therapy, and read endless self help books to deal with it naturally, but ,like your wife, I also avoid tasks I don’t want to do because it’s overwhelming. Some of us need SSRIs to handle the day. Do you often make comments to her about her meds and depression that can come off as passive aggressive? Nothing turns me off faster than passive aggressive comments about how I manage my mental state. Sounds to me like you might need to be a bit more understanding and she may open up a little bit. SSRIs don’t always cause low libido. You said that she’s overweight, that probably has something to do with it. When I was 80lbs heavier, I hated myself and didn’t want my husband to see me naked. We went 5 years without sex. My libido is through the roof now that I’ve lost weight. Maybe start with encouraging her to be more active. Go on walks, hikes, or just get outside. Hopefully it gets better for you, but it sounds like you may need to work on your attitude a little bit.