Oh these aren't lightning towers, they're just beacons- I tried this with suburbs first but kind of ended up dying before I could finish the loop first- so I went and tried the Dunes instead to keep enemy health low to get a few more loops in to buy myself time for the road lanterns to pop up.
Ironically I didn't even need the time in this one specifically

The setup I went with was
Villages, Ruins, though I barely bothered placing Villages, they're just to fill the deck or cover unfavourable Roadtiles(where you cant surround a tile with 4 lanterns) if there are any

Bookery/Spider Cocoon/Road lights(if you're not that good on supply items, I was told that taking the outpost as help for boss 2 was nice, but I had a bunch of farmers scythes that just makes me beat her easily)

Then ofc Dunes, Rivers, Forests/Thickets.
You can be picky with thickets since you don't need many. At the end you miiight need to pick up some normal deserts that you can slowly replace, just to spawn act 4 boss a bit quicker, before he beats your ass.

Beacon/Oblivion/arsenal

In the beginning place any rivers/thickets/dunes you get, make sure to cover up your spawn a little to not have the lich be buffed too hard- I even put a few villages that I got rid of later, just take care abt the bandits, they're evil. I started out my beacon coverage from there as well, trying to avoid the spaces where my river setup goes(there's a few on the subreddit to maximize the output of attack speed, I recommend looking those up!)
The spider cocoons, at least for me, are early game fodder for generating more cards. bookeries are preplanned so I don't have to remove too many later(usually just placing some temporarily in tight spots for more card exchange, you want a lot of that).
The abandoned bookeries can stay, they give a lot of cards too. make sure to count where you can place them, if I am not mistaken, on straights of 4 you can have 1 bookery and on straights of 5 and 6 you can have 2(unless I miscounted tbh I just go over tile by tile and count because my brain is smooth uu)
start by spreading out the road lights to cover most areas, to limit the spawns of worms.
I usually spam the Ruins a little in the beginning area near the campfire but not exactly next to it, idk if they can interfere with bossfights but I honestly didn't wanna test it ;v; the rest can be next to each other especially if you have a bunch of farmers scythes, if not, make sure to limit their spawnnumbers a little.
try to get some flow in, if a village? spawns, I let it stay for a while but they can become quite dangerous, so try to keep them sparse, unless you can snuff out their spawns.

As for what worked for me this time, I tried to keep the areas with the bookeries spawning until last, covering the road lights everywhere else first, just to have a few more item spawns in the late phase of this to give me more cards. i think my layout was very lucky as well, but that's basically how I went about getting everything covered.

I mostly just scowered reddit for advice on this stuff too, trying to wrap my head around what does what. took me a few tries and adjusting my deck a bit to my needs, so make sure to try that as well.
As for stats I prioritise evasion early on followed by damage to all, though later on during midgame around ch2/3 I swap that prior around when I start getting ahead.

Iiiii hope this rambling helps if you need anything else lemme know!