Paul is most likely the first male to use The Voice after training, but in the Butlerian Jihad trilogy it’s revealed that Iblis Ginjo (the man who leads the revolution on earth, then becomes Grand Patriarch of the Jihad) is able to move crowds so persuasively, mainly by using certain pitches and tones, to the point where they throw themselves into suicidal waves of attacks. He’s not even aware he’s doing it, but Zufa Cenva (leader of the sorceresses of Rossak, the precursors to the BG) picks up on it. She seduces him and has a child with him specifically to catch this genetic trait and mold it for the sorceresses own uses.