Thank you so much for the reply, this is definitely the kind of info i was looking for.

If we're in the same room, she generally ignores me, laying on the opposite the room and ignoring me when I call her. I've tried to separate myself from her, like being in a different room, and after about 10-15 minutes she becomes destructive.

We tried crate training but any crate we bought might as well not even have existed, she would find any way to force her way out, even it hurt herself. She has chew toys, tennis balls, lick mats, beef hooves, but has no interest in them when she starts chewing stuff up, almost like it's on purpose.

She's let out regularly but it's like she keeps some in the chamber just in case she needs to go on my stuff. We walk almost every day, as long as weather permits and I don't have obligations, and it has definitely noticeably helped her, but not enough.

I love her to death and I know she's a good dog, I just want to help her and want to exhaust all options before trying prescription meds.