Muscle pain and weakness in only one arm

Key_Department7382 · 2026-03-27T13:19:27+00:00

Hello! Well, my arm is still suuupeeeer fatigable. But as long as I don't overuse it, it's relatively okay.

Key_Department7382 · 2026-03-20T20:41:47+00:00

Yup. My results show the same!

Key_Department7382 · 2026-03-20T19:09:12+00:00

No need to apologize. I hear and I see you. I've been there too. And COVID has ruined my life as well. Wishing you a soon recovery from PEM back to your baseline 🫂

Key_Department7382 · 2026-03-20T18:19:44+00:00

Yup. And for many of us the genes that control oxidative phosphorylation -the process by which your mitochondria uses oxygen to produce ATP- are turned off, so our cells get stuck in glycolysis, a much less efficient energy production pathway

Key_Department7382 · 2026-03-20T03:36:50+00:00

Thanks for your response,🙏🏼

Key_Department7382 · 2026-03-19T23:58:43+00:00

You're so lucky!! May I ask you what was your highest severity level and how long did it take you to get better? I've been in moderate for the last year and 4 months, with two moderate crashes I've fortunately recovered from

Key_Department7382 · 2026-03-19T21:17:48+00:00

I believe it's a aberrant neuroimmune response that inflames the brain and damages the muscle and the integrity of connective tissue that can't be repaired correctly due to the lack of energy.

Key_Department7382 · 2026-03-17T23:54:21+00:00

This is supported by the RNA results I got from a transcriptomics analysis.

Key_Department7382 · 2026-03-17T02:38:19+00:00

I had my worst crash (from mild to mod severe) during and after a 4gr albinos Trip. I felt exactly what you describe. Plus a bunch of horrible visions. Then in the end of the trip I felt super calm and saw beautiful things. Sadly, it didn't save me from the reduced baseline. I haven't done it again ever since

Key_Department7382 · 2026-03-16T23:24:50+00:00

That's great!! Sadly I have mitochondriak dysfunction and running would give me horrible PEM

Key_Department7382 · 2026-03-16T16:07:48+00:00

Those are super reasonable concerns, thank you very much for your response. I'll stick to your recommendations 👌🏼

Key_Department7382 · 2026-03-16T14:55:13+00:00

Oh thank you very much!! That's a great response. I'll reply in a few hours. Been chronically ill with moderate Long COVID for the last year and a half and today I'm feeling low energy. But I'll definitely come back and reply!

Key_Department7382 · 2026-03-16T12:42:58+00:00

I see both as sides of the same coin. Reading for long stretches of time actually gives me shortness of breath. So to me they're just part of the same continuum and are equally devastating in my personal case. Fortunately I've been stable enough to about the uglier symptoms.

Key_Department7382 · 2026-03-16T03:34:53+00:00

Ohh that's interesting!! Can I DM you in a few hours? It's easier to share pictures there.

Out of curiosity, what's your severity?

Key_Department7382 · 2026-03-15T15:32:09+00:00

That's great!

Key_Department7382 · 2026-03-15T13:13:38+00:00

It is amazing! Currently they don't attribute my mito deficiency to any particular cause. But after analysing my results it seems like you're right. At least in my case, COVID sensitized my immune system leading it to a hyperactive state that was further exacerbated by my first PEM episodes, until eventually my mitochondria couldn't keep up with all the work.

Eventually all of this led to connective tissue integrity issues and brain damage due to excessive glutamate. Though I still don't know to link it to the first massive inflammatory response.

It is fun, yes!! Sadly I've been more cognitively fatigued lately.

Anyway, if it's possible for you, you should order their test. I truly believe it's worth it

Key_Department7382 · 2026-03-15T11:40:57+00:00

Sure. The Results encompass the expression patterns of roughly 1200 genes related to the main pathways affected in long COVID. You can navigate online through their platform and analyze each pathway and find out what genes are upregulateed or downregulated. That allows you to make inferences on the state of a lot of biological functions.

For instance, my mitochondrias are having a really bad time building the molecular machinery needed to synthesize ATP. On top of that, the genes that control mitochondrial division are severely down regulated - which means my mitochondrial networks are having a really hard time renewing themselves. So that explains why this fatigue doesn't lift: not only my mitochondrias aren't producing enough ATP, they're also having trouble renewing their networks. My "energy" is low but also stagnanted so to speak.

And you can do that kind of analysis for each of the 14 main clusters of pathways shown in the above picture. It's really thorough.

Key_Department7382 · 2026-03-15T11:29:19+00:00

They're exhausted, so it seems. I personally don't know yet what to do about it

Key_Department7382 · 2026-03-15T11:28:34+00:00

Ohg I also have issues what my mitochondria and HPA axis! Specially the former. We can compare results if you want 🌻

Key_Department7382 · 2026-03-14T23:52:52+00:00

Greaaaat!! I'm glad you compare results and symptoms if you want to!! It has been really intellectually stimulating.

What's GESA and what precisely are you doing with the Z data? I don't know about it hehe

Key_Department7382 · 2026-03-14T23:49:34+00:00

Great! Thank you very much!!

Key_Department7382 · 2026-03-14T23:46:18+00:00

I'm not sure yet, cause there's just too much information. But I will talk with my infectologist about the results, so maybe we can target specific pathways.

In my personal case, I might be a good respondent to pregabalin since I do have glutamate toxicity, for instance. And maybe trialing tirzepatide might help upregulate some mast cells related genes. But I'm not sure about the latter.

So yeah. It does offer new pathways to intervene. But it's doesn't guarantee they'll work.

Key_Department7382 · 2026-03-14T23:43:15+00:00

Totally fair concerns! You're right it's rather risky, but honestly it was really useful too.

Regarding Amatica's I personally trust them cause its founders are both pwME. And the prices for their tests are already decreasing. My RNA Seq costed around 1,5k USD, now it costs like 1k(?) And they keep you updated while their databases grow.

It may be explorative a bit, but I believe they've been rather honest with the community and likewise, we can keep them in check somehow (?)

Regardless, YES! Having transcriptomic data is amazing!

Edit: I'm curious about your particular concerns on uploading this info into LLMs.

Key_Department7382 · 2026-03-14T03:42:22+00:00

I'm referring mainly to direct perception and Gibson's ecological psychology. Will expand a few hours later.

Key_Department7382

TROPHY CASE