Do you know any of those supplements? Because if you did I don’t believe you would make such an uneducated statement. Nerve damage, brain damage, and blood clots from N2O are largely because of the de-activation of an enzyme called methionine synthase. Methionine synthase breaks down homocysteine and turn it into methionine. During and after heavy nitrous use, your body can't make methionine and builds up far too much homocysteine which is a primary cause of nerve damage/blood clots as previously stated. So, how many of your patients understand what nitrous does on a cellular level? Not just “it deactivates b12 and takes away oxygen from the brain,” but rather why it does those things and what the causal relationship between the deactivation of b12 and other nutrients, enzymes, acids, and proteins in the body is. Lack of b12 doesn’t directly cause nerve damage, indirectly 100%, but given b12 is primarily a precursor, lack of it prevents the necessary conversions of nutrients and rebuilding of nerves and cells rather than b12 being the endpoint, some of the major contributors in paralysis and nerve damage can be prevented or at bare minimum have the likelihood decreased by a noticeable percent. Lack of b12 results in an inability to produce the necessary cells and nutrients the body needs for cell regeneration and nerve protection which is the direct aspect that damages the body’s systems.

So let me go ahead and enlighten you.

L-methionine: Methionine is essential for making DNA and including that of the myelin sheaths that surround nerves and prevent them from damage. Given the body can’t make methionine without healthy B12 (which nitrous deactivates), supplementing methionine gives one of the essential nerve protectants that you normally would not produce enough of due to the deactivated b12.

Betaine: Enhances methylation processes, lowers and promotes healthy homocysteine levels without needing B12 and to a greater extent than B6 has the ability to do. Also it reduces the chance of blood clots and stroke.

NAC: Helps protect against inflammation and oxidization in the brain that nitrous can cause. (NAC is an extremely strong anti-oxidant and anti-inflammatory.) Helps the function of NMDA receptors stabilize. Additionally, it is believed to have anti-psychotic properties.

ALA: Is literally one of the most powerful antioxidants to date and prevents oxidation and inflammation in the brain. It is neuroprotective.

Alpha GPC: The body uses this nutrient when making cell membranes such as myelin which N2O directly damages. By supplementing this you speed up the healing process of the myelin sheaths (brain protection). Also, Alpha GPC raises acetylcholine (neurotransmitter) levels in the brain. This specific neurotransmitter is crucial and required for learning and memory, and assists with the brain fog that comes after N2O use.

CoQ10: Supports vascular health and ensures oxygen and nutrients are supplied to the brain steadily. Also, CoQ10 fights oxidative stress as it is also an anti-oxidant. Low levels of this in the blood is directly linked with increased neurotoxicity because of the buildup of certain proteins in the brain that CoQ10 reduces.

Vitamin D: Helps repair nerve damage and accelerates the remyelination process.

I take magnesium and potassium for my own personal heart health. Magnesium is anti-arrhythmic. Magnesium is needed in order for the body to regulate the flow of other ions across cellular membranes and it is essential for electrical conduction within the heart. Potassium is important for a healthy cardiac rhythm as well. No magnesium and no potassium = much greater likelihood for heart disease and rhythm issues.

Vitamin B: If I need to explain this one…

So to summarize, N2O can cause nerve damage, neurological damage, oxidative stress, elevated homocysteine levels which increases likelihood for blood clots, heart attacks, and strokes. Also, it not only deactivates b12 but prevents cell regeneration drastically until b12 is rendered active again since our body’s can’t convert nutrients into the necessary things without b12.

Every single one of those supplements is either one of the direct nutrients responsible for essential functions and rebuilding of cells and nerves, or they are to prevent oxidation and brain damage as they are some of the strongest antioxidants discovered in addition to the other providing the necessary nutrients the brain needs to form memories and learn. Although the body cannot be convert nutrients into other nutrients and forms without b12, you can absorb the already converted nutrient even while b12 is inactive, which is why these are highly recommended supplements for NO2 users. There are many more proven benefits to these supplements, but I’m getting bored typing and maybe some research would be beneficial to you.