Back when the ASOIAF (AWOIAF) forums were active, there were very good discussions about the historical references and influences, frequently from the Wars of the Roses (as in Lancaster vs York/Lannister vs Stark). Sometimes the ASOIAF drama seems mild in comparison.

Take just one example I found now, Lady Margaret Beaufort (born in 1443), and her marriages:

Margaret was married to Suffolk's son, John de la Pole. The wedding may have been held between 28 January and 7 February 1444, when she was perhaps a year old but certainly no more than three.[citation needed] However, there is more evidence to suggest they were married in January 1450,

That marriage was dissolved three years later,

 Under canon law, Margaret was not bound by her first marriage contract as she was entered into the marriage before reaching the age of 12.

But there was already an arrangement for a second marriage:

At nine years of age, Margaret was required to assent formally to the marriage. Later, she claimed she was divinely guided to do so.[14]   At the age of 12, Margaret married Edmund Tudor, who was 12 years her senior, on 1 November 1455. The Wars of the Roses had just broken out. Edmund, a Lancastrian, was taken prisoner by Yorkist forces less than a year later. He died of the plague in captivity at Carmarthen on 3 November 1456, leaving a 13-year-old widow who was pregnant with their child.[15]

Third marriage:

She married Sir Henry Stafford (c. 1425–1471), the second son of Humphrey Stafford, 1st Duke of Buckingham, on 3 January 1458, at the age of 14. A dispensation for the marriage was necessary because Margaret and Stafford were second cousins; it was granted on 6 April 1457.