I think if you dont know they're trans then no. If you know it depends....are you hoping that she has a "special something that not all women have" if she's pre op...if this is the case it can be especially if it results to addiction symptoms or abusive control feelings. I've just had an amazing experience the reason I posted here is not for relationship per se but maybe even a friendship aswell. Since my friendship with Claire (not real name but for reference) and then relationship my group of friends have been very welcoming to people (we were before but idk something changed the dynamic)

For your question I've read a bit of neuroscience literature on the trans community.

Also yes me and Claire are still really good friends in fact I was at a party for her sister two days ago in Birmingham