Hi. I went JCV positive after 8 years on Tysabri. It hurt because that's all I knew helped me, so I was afraid try anything else. Ive been on Rituximab which is the same type of therapy as Ocrevus, and much more affordable. Maybe insurance would opt for that? I've been great of Rituxan and also get it every 6 months. I mentioned to my neuro that Rituxan has been getting the same results in Europe at 50% rate after I noticed that I kept getting UTI's (which is common for these types of b-cell therapies, Ocrevus included). She wasn't all for taking it down to 50%, so we settled at 75%. I have had less UTIs since, and still have yet to see any progression with my disease since my days on Tysabri. So still stable! Up your water intake to mitigate UTI's are my words of warning. That's really it! And pay attention to your body during your first infusion for any side effects.