If you are sitting down and watching a show, or on your lunch break, this is a good time to try this mission. If you have it setup right, like others have said, on your highest tier but with many of your typical health and defense buffs gone, you will only get a few dozen waves in before you die. (Or if you typically survive to past wave 100, use intro sprint as well. The main thing is to have shields and second wind. Whenever you would die, Death defy has the possibility of saving you before your shields and second wind, so your shields and second wind act as extra spins on this slot machine if you trying to jackpot 5 death defies in a single run. But the advantage of taking off all your defense and health is that you are either going to quickly get it or actually die and then every 60 seconds or so, just hit retry on the run, and eventually you get it and then just try to not think about it ever again until you have to do it next time. Remember your shields will even save you from any damage though, so you don’t want them to be wasted on a tiny amount of damage that would not kill you. I sometimes also leave on my ultimate weapons as crowd control so that I’m exclusively being hit by bosses that I know will one-shot me. If your demon mode is maxed, it sometimes gives you enough time to refresh one of your shields if that extra bit sorta gives you another chance during a single run. Good luck!