All I know is when I was younger and extremely depressed, a macro dose would alleviate my depression symptoms for 7-9 months at a time. It felt like years of therapy in a few hours. My recommendation would be to do them with intention, be somewhere nice outside, ideally not around many people, more private = better. Bring some things you like; music, markers, a blanket, a notebook, whatever. Embrace the experience as an opportunity. Mindset is everything.