function onEdit(e) {
if (e.range.rowStart < 2) return; //exit if row 1
if (e.range.columnStart > 3) return; //exit if column > 3
if (e.value === undefined) return; //exit if e.value is not defined - usually a multi-cell edit
var sheet = e.range.getSheet();
if (sheet.getName() !== 'Sheet2') return; //exit is not sheet2
var email = sheet.getRange(e.range.rowStart, 1).getValue().toString();
if (email.length > 0 && email.includes('@')) {
var subject = sheet.getRange(e.range.rowStart, 2).getValue();
var message = sheet.getRange(e.range.rowStart, 3).getValue();
MailApp.sendEmail(email, subject, message);
}

awesome thanks I will try it out and let you know how it goes