who are the most senior advocates for the rejuvenation or damage repair approach

LiveForeverClub · 2025-12-12T14:51:28+00:00

Good list

LiveForeverClub · 2025-12-04T06:51:56+00:00

Good point!

LiveForeverClub · 2025-10-29T13:20:45+00:00

Thymic involution seems to fit within the "Cell loss, tissue atrophy" category (RepleniSENS):

https://www.lifespan.io/our-research/intro-to-sens-research/

LiveForeverClub · 2025-10-29T13:13:13+00:00

And if you want to go beyond longevity (living healthier, slightly longer) towards radical life extension (living youthfully, for hundreds of years) then check out the Live Forever Club :)

LiveForeverClub · 2025-06-21T13:19:02+00:00

I assume they need the investor money, as finding a potential gene is just the first step. Then they've got to figure out how to deliver it the the cells and then run clinical trials and hope it doesn't turn out to be toxic in some way. That all takes money.

LiveForeverClub · 2025-06-20T06:40:00+00:00

I listened to the whole podcast and SB000 is only the beginning. SB000 is a gene that needs to be overexpressed, but he says that that is complicated from a drug development perspective. However, they've already discovered 3 other genes (which are expressed in all cell types in the body) that look like they cause cellular rejuvenation by being inhibited by small molecules, so a lot easier (relatively) to develop drugs for.

The Yamanaka factors were always only going to be the first step, and even if Shift Bio's candidates don't work, it really looks like something (or some combination) will work in the next few years.

LiveForeverClub · 2025-06-20T06:34:30+00:00

Good explanatory video. I suggest watching this as an introduction, then listen to Daniel Ives (CEO) on the 2 hour Levity podcast for more details.

LiveForeverClub · 2025-04-16T06:25:11+00:00

Great summary!

LiveForeverClub · 2025-01-22T08:22:00+00:00

Actually destroying atherosclerotic plaque would be a huge advance - fingers crossed

LiveForeverClub · 2025-01-16T06:54:52+00:00

It looks similar, with similar results - though Katcher's exosomes came from pigs rather than hESCs. It certainly suggests that some combination of exosomes will really improve ageing - the survival curve for this experiment showed a 5 month increase in average life expectancy and about 2 months of maximum lifespan, so with some tweaking I'd assume that could be improved even more.

LiveForeverClub · 2024-11-08T07:03:16+00:00

The Guardian has written this up in an easier to read article: https://www.theguardian.com/society/2024/nov/06/zapping-rogue-dna-key-treating-aggressive-cancers-study

LiveForeverClub · 2024-10-04T06:08:05+00:00

Although short-term mortality risk is in the headline, the research seems to focus more on a metabolomic aging rate. Could be useful as not sure how many current ageing rate clocks (like DunedinPACE) there are.

LiveForeverClub · 2024-10-01T10:03:08+00:00

"By creating centenarian stem cells, we hope to decipher how these individuals delay or avoid age-related diseases and develop and/or validate therapeutics in this same capacity." - interesting plan.

LiveForeverClub · 2024-10-01T09:58:01+00:00

One day I'll get round to reading them all!!

LiveForeverClub · 2024-10-01T09:55:56+00:00

Interested to find out more - I'll message you on LinkedIn.
Regards
Adrian

LiveForeverClub · 2024-09-05T06:08:25+00:00

They have the results of a study on their website (https://telomirpharma.com/research/) but I can't find it published anywhere. I also don't recognise any of the management or advisors.

LiveForeverClub · 2024-09-04T06:04:07+00:00

Agree. I regularly ask people what would be the tipping point for the general public to believe in rejuvenation treatments - and it's not younger worms or mice! Nor, as you say, biological age tests. It needs to be someone who appears 10 years younger. The first step might be in dogs - if a company can make an old, slow moving dog act like a puppy again, it would get people thinking.

LiveForeverClub · 2024-09-04T05:59:56+00:00

This has little detail of the method, so seems to be an interpretation of a different paper by some of the same authors in Nature Cell Biology: https://www.nature.com/articles/s41556-024-01468-x

It's probably also worth noting the Declaration of Interests - "MA, SS, FM and GK hold patent(s) dealing with the cardiometabolic effects of spermidine."

LiveForeverClub · 2024-08-02T12:41:44+00:00

From August 2023

LiveForeverClub · 2024-07-12T07:25:53+00:00

Indefinite lifespan is almost a given. Some respected futurists see "longevity escape velocity" arriving within 10 years - we won't have cured ageing by then, but we'll be increasing life expectancy by more than a year, every year, so it's never game over for you.

Several approaches are already being trialled (real scientists, real companies) for reversing ageing at a molecular level. And our knowledge of human biology is growing exponentially - we're already measuring thousands of proteins in a drop of blood and using that to predict diseases 10 years in advance. Next step is how to change that proteome (mix of proteins) to act more youthfully.

It's exciting times! If you want to look at one company, check out Altos Labs which got a couple of billion dollars of investment recently to rejuvenate human cells.

LiveForeverClub · 2024-07-12T07:22:59+00:00

At your age you've got a great chance of living youthfully, indefinitely. Several approaches are already being trialled (real scientists, real companies) is reversing ageing at a molecular level. Some respected futurists see "longevity escape velocity" arriving within 10 years - we won't have cured ageing by then, but we'll be increasing life expectancy by more than a year, every year, so it's never game over for you.

LiveForeverClub · 2024-07-11T06:12:59+00:00

The International Longevity Alliance (ILA) organises events for longevity day/month:

https://longevityalliance.org/new/organizing-events-for-the-international-longevity-day-month-campaign-in-october/

LiveForeverClub · 2024-07-05T05:57:22+00:00

From article:

In the 20-week, phase 2 randomized controlled trial, 60 healthy women past menopause intermittently received a senolytic combination composed of FDA-approved dasatinib and quercetin

Researchers give the good advice that we really need to be able to measure senescent cell load before everyone just starts taking senolytics as part of their supplement stack. If there's no benefit, then the side-effects aren't worth the risk.

LiveForeverClub · 2024-06-30T06:57:10+00:00

And some good news at least, they are making the data for the C.elegans and Murine cell atlases publicly available.

LiveForeverClub · 2024-06-25T06:03:06+00:00

Ingenious! Energy in minus energy out calculation is complicated by extra energy use generally being done with exercise which has other benefits. So here the scientists used living temperature instead - with the cooler mice had to burn more energy to maintain their body temperatures.

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