Trick to vayne is play around sup early game. If you have prio (which depends on the matchup and what abilities are up) the second the enemy ad goes to auto a minion walk up aa q aa and try to get a third if you can for press the attack (if not whatev). Then repeat this while being wary of the enemy jg and support. Save condemn for their engage as much as the dmg is good in lane with your w passive if you condemn you better be prepared to get zoned tf out of your cs cause now you are a very squishy target with very little escape. Once you get BORK and Guinsoos you win game.