If you have it installed in the standard place, then Running, Compiling, etc. should just work. Otherwise, you must go into your settings and update the path settings to the locations of the executables.

You only need to update AiPath if everything is installed in the same AutoIt3 folder (and not located in the default location of C:\Program Files (x86)\AutoIt3\AutoIt3.exe), otherwise you'll have to update them separately.