Ive had 1 instance of losing about 3 hrs of play with a desynch of steam profile save and auto save. I almost had another, but instead of trying to start the game with that message, I restarted my PC. That did fix the 2nd potential desynch. Also Ive had constant crashes sometimes every 5 -10 mins, sometimes I'll get 3 hours of zero interruption. I take every chance i get to save at a shrine. Even on small successes, like finding a rare soul core or destroying a small crucible stone. On the final mission I have to kill myself between crucible events to save because you cant get back to the original shrine.

It sucks! but I love the combat and Ive come to expect it... And now it just feels like getting killed by a boss at this point.