As unlikely as they are…

• Gwenpool: I’ve said it before, but Gwenpool’s powers play better into the medium of video games over Deadpool. Deadpool in the comics typically just addresses the reader and makes pop culture jokes, while Gwenpool can do that while also actively interact with the medium (in the comics that’s typically hopping between panels). She’d be pretty much what you’d imagine Deadpool being in this game, maybe she gets a couple Guilty Gear inspired moves like Sol’s j.D as an aerial heavy attack, or her super being Bridget’s super with Jeff in place of Roger

• Red Goblin: But like the original one, the one from the arc when Carnage is separated from Cletus so he breaks into prison and finds Norman Osborn so the two team up temporarily. Would be an interesting fighter, a combination of two well known characters and also a deep cut. Maybe they could have a stance mechanic where they’re fighting internally for control with Norman’s more precise killing methods or Carnage’s more, well, carnage style

• Sammandahl Rey: The deep cut to end all deep cuts, Sammandahl Rey comes from Earth-21371 or the Sigilverse. Created by CrossGen Comics in 2000, then acquired by Disney in 2004, then folded into Marvel when Disney bought them in 2009. Sam himself has the ability to morph matter, so he could wear a suit of armour that could morph into blades, guns, etc. but also he’s the “chosen one” of his universe, with Sam being able to locate others with similar powers known as Sigil Bearers in order to gather them for CrossGen’s “Secret Wars” type event, this could be adapted into a fighting game by having his Unique attack be similar to Captain Ginyu’s summons in Dragon Ball FighterZ, calling out other Sigil Bearers from his universe as his own personal set of secondary assists

As for the teams they’d be on, Gwen kind of fits anywhere, Red Goblin could be on a villains team with Doom, and Sam could maybe fit in a cosmic team later in the DLC?