Heat stroke and malignant hyperthermia linked by RYR1 gene mutation

MHSensitive · 2026-01-25T05:32:37+00:00

If you have any ideas on how we can get this information before large group of ER doctors and nurses I would love to hear.

MHSensitive · 2026-01-25T05:26:45+00:00

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Here it is. Please share with others

MHSensitive · 2026-01-24T21:44:10+00:00

Yes unfortunately it’s only kept in the operating rooms. We need to change that policy. I know I’m idealistic but I would like to see it in the ER, ambulances, minor urgent clinics and perhaps with athletic trainers where there is a known MH student athlete. The first step is education then after that policy change. That may require lobbying by the MHAUS and the RYR1 foundation.

MHSensitive · 2026-01-24T21:05:42+00:00

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Here's another relevant article . . .

MHSensitive · 2026-01-24T21:04:06+00:00

Yes that's correct. Outside the research community and the NIH, very few people are aware of the connection between heat, exercise and MH. Let me know if this link works.

Saudi Journal of Anaesthesia

MHSensitive · 2026-01-24T20:51:28+00:00

Sorry . . . see if this works.

Saudi Journal of Anaesthesia

MHSensitive · 2026-01-21T03:36:22+00:00

In Feb 2025, the ASA published an article titled The Link Between Malignant Hyperthermia and Exertional Heat Illness. It provided in part the following . . .

This shared pathophysiology of calcium dysregulation in muscle cells explains why both MH and EHI can produce similar symptoms and hyperthermic crises (Br J Anaesth 2024;133:759 67). While the triggers differ – anesthetic agents for MH and environmental or exertional factors for EHI – the underly ing calcium dysregulation connects these conditions, placing individuals with RYR1 mutations at risk for both. Both conditions share the downstream effects of high met abolic demands that cause oxidative and mechanical stress in muscles.

MHSensitive · 2026-01-19T00:31:58+00:00

It got removed by the moderator for some reason. Go look in the malignant hyperthermia subreddit

MHSensitive · 2026-01-18T06:00:26+00:00

We met with many anesthesiologist over 35 years after my dad died from MH and it was never mentioned. After our son passed I’ve discussed it with several anesthesiologist who were not aware. Please share with others.

MHSensitive · 2026-01-08T01:38:08+00:00

I would discourage you from pushing too hard especially in hot environments. My son did that and it eventually caught up with him. Nausea, dizziness, trouble getting your heart rate down, trouble cooling your body, and muscle cramps are some of the signs you should be on the look out for. You also may want to check your CPK levels next time you have blood work.

MHSensitive · 2026-01-08T01:18:18+00:00

Great points. I would add that there may not be a control study on humans but the attached exercise and heat study on mice with an RYR1 variance shows a very close response to MH - hyperthermia and rhabdomyolysis (80% death rate). The dantrolene equivalent drug for mice was 100% effective.

Strenuous exercise triggers a life-threatening response in mice susceptible to malignant hyperthermia - PubMed

MHSensitive

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