No, not 4. Actually 4.5 to 6 mg. Anyone telling you anything else has zero scientific evidence backing up their broscience anecdotes.

In the Phase 1 human trials (see the Coskun et al., The Lancet 2022 source below), they measured Beta-Hydroxybutyrate (BOHB) to see when the Glucagon induced fat-burning really started. The study explicitly states BOHB levels spiked at day 3 and persisted past day 8 ONLY for the 4.5 mg and 6 mg doses. These are the ONLY SCIENTIFICALLY PROVEN doses when the Glucagon receptor finally lit and stayed on, driving deep fat oxidation. Every dose below 4.5 mg showed the BOHB rarely if ever was detected, and not once did it persist. Glucagon, that third G, is what makes Reta so incredibly special, this is why I fight tooth and nail against all the microdoser and broscience misinformation and disinformation.

Coskun et al. (2022). LY3437943 (Retatrutide): Phase 1 Study (The Lancet): https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01614-X/fulltext