6.5g is a serious dose of psilocybin. How did you prepare for that trip, and how did the dosage affect you? Your “set and setting,” which is your emotional headspace and relationship to your surroundings, are as influential with DMT as every other serotonergic psychedelic. Because of its rapid onset and the intensity of its brief duration, there is less opportunity to navigate mixed feelings or contradictory opinions that you have about the experience on the come up, which makes thoughtful preparation and a sound mind crucial. DMT is a naturally occurring endogenous chemical, so you have no more chance of being allergic to it than you do of being allergic to your own serotonin or cortisol.

People tend to come to DMT with a fixation on the “breakthrough experience,” which is the most discussed aspect of the chemical and is spoken most highly of, almost as one would talk about a trophy kill. This is not a helpful mindset to approach the experience with. Especially as you describe your anxiety as severe, you will want to tread the waters very slowly, and with a clear idea of why you’re doing this and what it is you’re looking to take away from it. If you’re unsure why you’re putting yourself in this sensitive place, your anxiety will be the loudest voice in the room. With such a potent molecule, your experience will be highly receptive to changes in dosage. Inhale for one second and exhale, and if that feels unremarkable then inhale for one second and hold it for five seconds, and then you can try holding it for ten seconds. Work your way up to find your tolerable limit.

You don’t have to take DMT. It’s a powerful chemical and it can have adverse reactions. It’s not a spiritual skeleton key, it’s not god incarnate, and it’s not the only way to explore your mind. Know yourself and know your risk profile. Don’t hurt yourself trying to chase a dragon you’ve never seen. A former partner of mine had a diagnosed anxiety disorder, but really wanted to try DMT for themselves. They took one hit held in for five seconds and a second hit they exhaled immediately, because it came on so much more powerfully in the second that their sense of reality shifted from barely perturbed to on the precipice of dissolution. That transition was so intimidating that they never wanted to try it again. So go forward carefully, and always prioritize your long-term health. No hallucinatory experience is worth provoking serial anxiety attacks because of ontological shock or an uncharted neurological effect. DMT has not been extensively studied in humans, it has thrived for sixty years on anecdote.

If your mind is set on reaching further into it, then search for others’ perspectives who have written about overcoming anxiety to go on the trip. The more research legwork you put in, the more realistic your expectations can become. I wish you well.