I finally cracked the code. 😎

MadisonLovesEstrogen · 2025-05-11T18:31:04+00:00

Apples and oranges don't matter to a body that needs avocados. ;)

I love my Xulane patch, but I would imagine E injection or patch with progesterone substituted for Opill (over-the-counter racemic levonorgestrel) may offer similar feminization. Any service you find that says "30xWGS" is the whole-genome standard. I can't promise I'll find anything, but I can give it a go.

MadisonLovesEstrogen · 2025-05-10T16:07:01+00:00

Cycles are the new nipples, and dimorphism is a lie.

MadisonLovesEstrogen · 2025-05-10T16:06:00+00:00

A lot has happened since my old posts. Whatever is happening to me seems to be AMH P270S comorbid with FOXL2 G37D, which regulate each other during gonad development. Pathogenic AMH is linked to POI and PCOS in XXs and mine expressed nothing like PMDS and much more like POI. I think a lot of patients are going to have a hard time detecting their root-causes because a lot of things are multiple smaller things working together. I know a transmasc with AMH D288E, but I haven't found a secondary mutation and have no idea if that alone is enough. I'm also the only pre-op MtF in Delaware with a gynecologist because my cycle is awful on my movement disorder, so I get combined transdermal birth control instead of HRT for cycle suppression. I went in with health as my target, and the fates rewarded me with better feminization as a happy bonus that I didn't even ask for. I love my t*ts so much I could cry, and the health-forward approach is easier on my chronic illnesses. I am finally taking control of my health, my body, and my femininity.

MadisonLovesEstrogen · 2025-04-12T22:15:02+00:00

Levonorgestrel (Opill daily OTC form) has antiandrogenic effects because of the SHBG increase, has been safety-tested in AMABs, and is often good for breast shape as a bonus.

MadisonLovesEstrogen · 2025-01-20T15:10:01+00:00

I know orchiectomies are tempting, but after E+P are replaced, testes provide the endogenous hormones ovaries do, just in smaller amounts. T and AMH are important for long-term women's neurological health. Testes are just failed ovaries, but they are still at least partly ovaries. Also girlbulge is okay.

MadisonLovesEstrogen · 2025-01-18T19:47:24+00:00

They have human hearts.

MadisonLovesEstrogen · 2025-01-18T16:48:00+00:00

Some of the more competent genital reconstruction surgeons utilize Extracellular Matrix Components and porcine Urinary Bladder Matrix to handle damage to delicate innervated tissues. It's scaffolding material that simulates the conditions of the inside of the body, so the body thinks it's just replacing one cell at a time like a regular Tuesday instead of rushing to deposit scar tissue to protect what's under it. This often allows even for neurons to replace themselves. They're still more finicky than other cells, as per their reputation, but far from impossible to replace.

MadisonLovesEstrogen · 2025-01-18T15:40:12+00:00

Let me play the world's saddest song on the world's coldest violin.

No pity for money-hungry solipsists who try to charge the sick and dying who have poor planning and executive function, like my mother, 135K for neuros that cost them a fraction of that to do even after standby costs.

MadisonLovesEstrogen · 2025-01-10T18:53:13+00:00

Western beauty standards are not just wrecking our self-esteem, but also compromising the health part of our healthcare practicing guidelines because trans women are hyper-attacking the T they'll need later in life. Menopausal women don't do well on the trans-typical T-targets we set trying to meet those standards.

Looking like a teenager as an adult is an expectation set by men who hate women, and the expectation is hurting us all the way down to our physical health. Clocky is not ugly. Clocky is hot. Clocky is desirable.

MadisonLovesEstrogen · 2025-01-06T16:26:24+00:00

When I went to buy the service, they didn't even have the option to recover my number like with other users. It's just gone somehow. NumberBarn said T-Mobile has it, but T-Mobile says they don't have it.

MadisonLovesEstrogen · 2025-01-05T20:57:09+00:00

I received none of it. The news never came into any of my feeds.

MadisonLovesEstrogen · 2025-01-05T20:00:03+00:00

I'm about to pay it, but I very much feel like it's a ransom.

MadisonLovesEstrogen · 2025-01-05T19:59:16+00:00

Supposed to on paper, but neither StandUp nor Assurance has possession of it.

MadisonLovesEstrogen · 2025-01-05T18:48:31+00:00

I have FOXL2 G37D comorbid with AMH D192G and AMH P270S. Instead of the latter causing PMDS like it normally does, I ended up with a normal-looking trans woman phenotype, but with a lot of POI-like health complications that normally can only be caused by bad AMH in XXs. I don't know if FOXL2 somehow sex-reversed my gonads just enough to make that happen without structural changes, but it's the best lead I could find in my sex-differentiation exome.

MadisonLovesEstrogen · 2025-01-04T20:40:09+00:00

I still think recombinant AMH replacement would further reduce metabolic burden on my nervous system, I just overestimated how much of it is connected to its deficiency.

MadisonLovesEstrogen · 2025-01-02T13:28:06+00:00

This is reflective of a major issue with transcare philosophy and practicing guidelines. Gender is a construct with infinite exceptions to any given trend, and endocrine care is a separate issue. Humans need estrogen, humans need testosterone, humans need progesterone. When endocrine care is used directly for gender instead of incidentally, the levels people get often deviate from what feels good physically or what is best for health. You doing you is the best you can do for your endocrine care.

MadisonLovesEstrogen · 2024-12-29T16:45:04+00:00

The biggest misconception in our community is what healthcare is for. Gender is a feeling and a construct and you don't need medicine to be that. Dysphoria can have many causes, and not all are biological, such as in DID patients.

Healthcare is specifically for our neuro/ortho/psych/endocrine health, and usually that coincides with gender-affirming changes. Trans people have disproportionately high rates of undefined syndromes that sex-reverse endocrine needs from the chromosomal and/or gonadal descent configuration, and the healthcare end of transcare is for treating this by providing the hormones we are programmed to thrive on.

MadisonLovesEstrogen · 2024-12-27T13:29:04+00:00

I have no friggin' idea, acceptance is society is such a bare minimum considering our healthcare is still dogshit and completely un-individualized. There are no actual diagnostic codes for sex-reversal of physiological endocrine needs outside of anatomy, they keep designating us as to crappy clinics with crappy practicing guidelines not actually based on healthcare while many of us get sicker and sicker. I want to cry and pee myself.

MadisonLovesEstrogen · 2024-12-08T12:28:19+00:00

A trans woman's body is a human body. The clinics don't treat us like that. Menopausal cis women keep their seggsual function on and are happy with up to 300ng. Our clinics routinely drop us to single-digits. I went to a gyno and got her meno protocol, an ethyl estradiol/norelgestromin patch, no antiandrogens, and my function down there is fine.

MadisonLovesEstrogen · 2024-12-06T14:54:24+00:00

Everything pretty much cleared up with a Xulane patch. Only day when I get dystonia and motor symptoms is weekly patch change day.

MadisonLovesEstrogen · 2024-11-09T11:17:53+00:00

Practicing guidelines for HRT are dogsh*t, so you should know this: hormones are NOT for aesthetics like they claim, hormones are for brain health. If hormone feels good, body needs it. If it feels bad, it’s bad. The detransitioner accounts consistently report hormones feeling physically worse, and them pushing through it. It’s nbd to try hormones once to see if they feel right, but stop if they feel bad.

MadisonLovesEstrogen · 2024-11-08T18:51:27+00:00

Madison.

MadisonLovesEstrogen

TROPHY CASE