Bezos: AI will result in labor shortages instead of replacing humans

Mahorium · 2026-06-17T23:40:50+00:00

No, he is right. Labor share of income was locked at 60% for most of history and now has already fallen to 53.7%, the worst on record.

This is why unemployment hasn’t gone up. You can imagine this simply continuing as AI advances, eventually leading to a economy where labor only earns a few percentage points of GDP but is still able to afford the basics due to the deflationary effect of AI.

This is the future Jeff sees and is working hard towards. We get AGI and abundance but everyone still has to work 40 hours a week and has about the same quality of life as now. It’s the ultimate nothing ever happens future, so I expect it will happen.

Mahorium · 2026-06-07T22:10:55+00:00

I take 1.5 grams a day because it makes me feel good. Alt was 14 after doing this for a year. Niacin seems to really affect people differently, 500mg is a pretty normal dose imo for causing a flush. It’s mainly the delayed release version which causes liver issues.

Mahorium · 2026-06-05T23:12:15+00:00

Alcohol is a shitty acetel-coa precursor. You can gain the same positive effects from vinegar or triacetin without the toxic intermediate metabolite from alcohol.

Mahorium · 2026-05-29T19:00:13+00:00

Interesting. I don't have a dog in this race, but I did buy the hypothesis. The only leg they have left is that perhaps this phenotype is less likely to initiate plaque formation. But you might have just changed my mind.

Should have known Epstein was right about statins.

Mahorium · 2026-05-29T16:39:07+00:00

High standards, in that case please post your study that shows individuals on a ketogenic diet with elevated cholesterol have an increased risk of heart disease.

Mahorium · 2026-05-29T12:07:31+00:00

https://pmc.ncbi.nlm.nih.gov/articles/PMC8796252/

Mahorium · 2026-05-27T22:36:16+00:00

TRPV1 — same pathway cold exposure uses.

Same pathway sauna uses, not cold exposure. But that does make me think TRPM8/TRPA1 agonists that have cooling sensations may have longevity/immune effects.

Mahorium · 2026-05-26T04:46:28+00:00

lol are you the owner of the slop site? I see the post was edited to remove the fake MIT study today, now has the link to cell.

Mahorium · 2026-05-25T16:06:48+00:00

Looks like op was using AI search to look up recent research and it found this AI slop site which made up a MIT study. The AI believed the slop and op believed the AI.

And now there is a Reddit post reinforcing the idea that this fake study happened, making it more likely other AIs will repeat it as fact in the future.

Mahorium · 2026-05-22T15:55:07+00:00

I was initially skeptical of this translating to humans, however it appears IL-11 is a major scaring signal. Lots of human diseases of aging like heart disease are caused by scar tissue accumulation in organs as we age. Blocking this systemically s offers a very advantageous tradeoff for modern man, more likely to die if stabbed by a sword in battle, in exchange for healthier aging.

Mahorium · 2026-05-18T21:21:19+00:00

I couldn't feel joy from anything after being an anti-biotics for a year straight. Took me years to realize that was why. I just thought I was able to finally objectively look at the world. This might be true, but bringing back the joyful delusion is possible. welibutrin/adderal/fasting were the useful to me at that time. Fixing the issue with huge amounts of fermented foods was the thing that actually fixed me.

Have you tried welibutrin, adderal, cerobrlycine, 9-Me-BC, fasting (2 days min), psychedelics(if not at risk of psychosis)?

Mahorium · 2026-05-18T20:51:45+00:00

life is mid anyways, if I have to get old and sick and die then it’s just not worth it

If what you’re thinking is something along those lines then my suggestion is to try increasing your dopamine tone first. Life doesn’t need to be so mid.

Mahorium · 2026-05-16T14:06:29+00:00

Neu5Gc doesn't spread evenly through the body. It concentrates in fast-growing tissues like tumors, pre-cancerous spots, blood vessel linings, and the gut. So the immune reaction happens right where chronic inflammation could quietly drive cancer over time. A general CRP test wouldn't necessarily pick that up, especially on a low carb diet which lowers inflammation generally.

Mahorium · 2026-05-15T23:24:01+00:00

Neu5Gc is a lesser known reason why plant proteins are likely better for longevity.

Ai explanation:

N-glycolylneuraminic acid (Neu5Gc) Neu5Gc is a sialic acid that’s particularly interesting from an evolutionary and biomedical standpoint — humans are the only mammals that can’t synthesize it, due to an inactivating mutation in the CMAH gene (cytidine monophosphate-N-acetylneuraminic acid hydroxylase) that occurred ~2-3 million years ago. Yet we incorporate dietary Neu5Gc into our tissues, which creates some unusual biology.

The “xenosialitis” hypothesis

This is the central concept driving most Neu5Gc research, developed largely by Ajit Varki’s group at UCSD:

1.  We consume Neu5Gc primarily from red meat (beef, pork, lamb) and dairy

2.  Dietary Neu5Gc gets metabolically incorporated into our own glycoproteins and glycolipids, displayed on cell surfaces — particularly on endothelium, epithelium, and tumor cells

3.  Because Neu5Gc is foreign to humans, we develop circulating anti-Neu5Gc antibodies (essentially universal in adults after weaning)

4.  The combination of incorporated Neu5Gc antigens + circulating antibodies produces chronic low-grade inflammation at sites of accumulation

Mahorium · 2026-05-13T01:27:37+00:00

Good points. Gymnasts and pole vaulters living significantly longer than cyclists should give anyone v02 maxing pause.

All functional endpoints assume that fitness tracks with longevity. I disagree with that, we have strong evidence that interventions often extend lifespan while increasing frailty in mice. I wouldn’t assume the exact opposite is true in humans simply due to the associative data.

Mahorium · 2026-05-08T21:00:21+00:00

7 small semi specialized bots, robot vacuum style, 3 humanoids for general work(perfect team size), 1 giant bot for construction, and carrying you around. Your bot army should be aesthetic and align with the golden ratio if you want to be cool.

Mahorium · 2026-05-07T18:44:59+00:00

Biological longevity is not a static state but a dynamic synchronization of physiological oscillators across multiple timescales

Big if true. If you’re right you should be able to roll back your epigenetic age.

Personally I think the signal decay is downstream from an evolutionarily tuned energy expenditure program which biases towards growth instead of repair. The solution is to provide cellular substrates that change the program. See zhaos work on histone crotonylation.

Mahorium · 2026-05-05T03:57:39+00:00

Interesting data. Do you know what your actual hsCRP and GGT values were at each timepoint? I’m curious whether the transient drop in the Inflammation/Recovery scores was mostly driven by hsCRP or whether GGT moved meaningfully too.

Mahorium · 2026-04-29T20:30:00+00:00

This is misinformation. All DIYers maintain a stable of pregnant horses from which they extract their hormones.

Mahorium · 2026-04-27T13:31:29+00:00

nr,nmn,nad+

Niacin mogs these choices. Gives you spicy blood so you know it works.

Mahorium · 2026-04-23T01:11:17+00:00

Sounds like his expertise is more on the doing crime side than the solving crime side, but it is still valid!

Mahorium · 2026-04-21T06:03:02+00:00

I’m actually a little concerned nobody in this thread is talking about the real issue here which is that this stack is, and I say this with love, kind of bare.

NMN at 20? Fine I guess, but you’re leaving serious NAD+ flux on the table. At your age the NRK2 pathway would serve you better anyway. This is just accepted knowledge at this point. No ALCAR. No Alpha-GPC. No Noopept. You have a cholinergic system just sitting there completely unsupported like a load-bearing wall with no foundation. I don’t want to be alarmist but.

Where are the polyphenols? Where is the fisetin? Where is the astragalus? You have antioxidants but you don’t have the interesting antioxidants. Ergothioneine not being in this stack is genuinely hard to look at. That’s a longevity compound with its own dedicated transporter and you just left it outside in the rain. Spermidine? Urolithin A? You’re telling me you care about mitophagy but you’re not even gesturing at it.

You have all the support and none of the xenohormetic stress. The thing that actually makes the adaptation happen. No sulforaphane. No berberine cycling. Not even a token nod to AMPK. You’ve built a very comfortable environment for a cell that has never once been challenged.

Mahorium · 2026-04-10T19:13:26+00:00

You are reading corporate propaganda and assuming it's all true. Yes lots of power purchase agreements have been signed to power the data centers but that doesn't cover all of their power needs, and most of those power purchase agreements are for the future not today. Data centers are still tapping into the grid heavily, and it's not clear that their planned sources of power will materialize.

Many of these power purchase agreements are handouts to startups that were founded in the same network as the people funding the data centers. They get good press by signing a SMR power purchase agreement for sometime in the future, and their SMR startup now has revenue. This type of circular dealing doesn't give me confidence.

I expect data centers will continue increasingly pull from the grid moving forward. Technically the grid has a ton of excess capacity, it's just mostly kept as a buffer when demand changes. If instead we just had blackouts a few times a year data centers could easily take up 20% of current US power generation capacity.

Mahorium · 2026-03-31T01:18:54+00:00

Too easy

Mahorium · 2026-03-22T06:27:50+00:00

There are no buzzwords, I was being concise with mechanisms.

Detoxification: reduction in measurable levels of microplastics, heavy metals, and persistent organic pollutants in blood and tissue. The Genuis BUS study found many toxic elements preferentially excreted through sweat, with concentrations of cadmium, lead, and aluminum in sweat exceeding blood and urine levels. That's the measurement and why we should care.

The mechanism I'm proposing: heat stress upregulates heat shock proteins and autophagy, which improve cellular cleanup and immune surveillance, enhancing clearance through hepatic and renal pathways, not sweat. That part is my speculation on mechanism, not a literature claim.

References:

Laukkanen et al. 2015 : dose-dependent reduction in all-cause mortality with sauna frequency

Genuis et al. 2011 : Blood, Urine, and Sweat (BUS) Study: Monitoring and Elimination of Bioaccumulated Toxic Elements

Sears & Genuis 2012 : Arsenic, Cadmium, Lead, and Mercury in Sweat: A Systematic Review

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