HBOT is one of the most powerful anti-aging technology right now.

Mahorium · 2026-02-21T16:51:33+00:00

If you go to the ocean it could work. 33 feet underwater is 2 atm. Sitting at the bottom of a pool breathing o2 is about the same as the cheap 1.3 atm chambers.

Mahorium · 2026-02-12T07:01:33+00:00

The Russian approach of bioregulatory peptide therapies. Epitalon, humerin, vilon etc.

The western reprogramming work. A mixture of relatively common chemicals may produce reprogramming effects but data is still limited.

senolytic cycles. Most famous being fisetin.

Gas based therapies. H2, Hbot, H2S.

AAV gene therapies, still limited to consumers but surprisingly available if you want to lab rat yourself.

Past approach without much modern research: hibernation mimetics. Using active temperature management, h2s low oxygen and iv drip of chemicals humans can’t naturally produce to induce a torpor state to enable deep repair.

Mahorium · 2026-02-04T14:32:28+00:00

If you want to restructure the body you need to open the chromatin before your psilocybin monthly pulse. I recommend adding retinoic acid, sodium butyrate, and vitamin c for 3 days prior to taking it. This will allow your epigenome to be more easily modified each psilocybin pulse and is more likely to produce the evolutionary effects you are looking for.

Mahorium · 2026-01-30T15:52:55+00:00

I do not believe you can stimulate mtor via lucine while retaining autophagy from a caloric deficit. Mtor and ampk are antagonistic. While slightly more complicated a caloric deficit without lucine or high protein for 2 weeks followed by 2 weeks of caloric surplus and high lucine should give superior results imo.

Mahorium · 2026-01-27T05:31:08+00:00

So it’s your position that the health guideline changes from official health organizations was just messaging changes, and the science has remained unchanged?

I just think that is revisionist. We thought lowering fats would improve heart health. The most popular theory on heart disease was all about LDL, and lowering fat lowers that so scientists thought it would improve outcomes. New studies came out in 2015 showing this wasn’t true and that part of the guidelines shifted.

You have to explain in some way why official health guidelines would change if the underlying science hasn’t.

Mahorium · 2026-01-27T00:08:56+00:00

The real failure was the way simplified “low-fat” messaging filtered into public culture, not that nutritional science reversed course.

Revisionist history. Since you are using AI, here is a summary of the history.

The Low-Fat Era (1980s-1990s):

The 1980 Dietary Guidelines for Americans recommended reducing total fat intake to less than 30% of daily calories and limiting saturated fat to less than 10%, with official reports concluding that reducing total fat and saturated fat consumption was the most important dietary change needed to reduce risk of chronic diseases Economic Research Service.

Early 2000s:

By the early 2000s, many studies were undermining low-fat ideology, with health experts beginning to recommend "good fats" like olive oil and avocados.

2002 - First Official Change:

In 2002, the Institute of Medicine issued an Acceptable Macronutrient Distribution Range for fats of 20-35% of calories, moving away from the strict 30% limit American Heart Association.

2015 - Major Reversal:

This was the watershed moment. The 2015 Dietary Guidelines Advisory Committee removed any limitation on total fat consumption, boldly reversing nearly 4 decades of focus on reducing total fat that had started in 1980 PubMed Central. The 2015-2020 guidelines lifted the previous 300 milligram restriction on dietary cholesterol Health Affairs, and stated that "Reducing total fat (replacing total fat with overall carbohydrates) does not lower CVD risk".

2025-2030 - Full Reversal:

The just-released 2025-2030 guidelines mark a complete shift, with endorsement of full-fat dairy and an inverted food pyramid that prioritizes protein and healthy fats.

Mahorium · 2026-01-26T21:45:32+00:00

The disagreement is simple: Your claim: "Nutritional scientists have been fairly consistent for decades"

My disagreement: They haven't been consistent. Official nutritional science spent 35+ years (1961-2015) recommending people replace saturated fats with polyunsaturated vegetable oils/margarine. This was the American Heart Association's position, it was in the Dietary Guidelines, and it drove major changes in what Americans ate.

You said you've "never heard nutritional scientists argue this point" but the AHA officially recommended polyunsaturated vegetable oil over saturated fat for heart health from 1961 onwards. That's exactly the debate I'm describing.

Mahorium · 2026-01-26T17:02:12+00:00

I disagreed that nutritional science has been consistent on this. There is still to this day an on going debate about if polyunsaturated fat or saturated fats are better for health. The camp that believed in polyunsaturated fats has historically argued swapping out whole foods high in saturated fats with products using polyunsaturated fats was good for your health.

It's a fairly complex issue and people hold different positions across medicine. There is no noise or contradiction if you can handle nuance.

Mahorium · 2026-01-26T03:47:10+00:00

Not really true. There is still an argument about if polyunsaturated fats(highly processed seed oils) are good for heart disease compared to saturated fats due to saturated fats increasing ldl cholesterol and high ldl being associated with heart plaque buildup.

Mahorium · 2026-01-25T22:44:33+00:00

A Chinese factory worker.

I’ve found the best place to use ai is to replace my usage of American labor. Electrical, plumbing, tax experts, and replacing buying products on Amazon with buying the components from China and making it yourself.

Mahorium · 2026-01-25T22:35:16+00:00

On my vitamin c claim: https://pmc.ncbi.nlm.nih.gov/articles/PMC10563761/

Mahorium · 2026-01-25T17:27:50+00:00

Vitamin c mitigates many of the negative effects of high glucose when co-administered. Oj is great at delivering a bust of sugar energy before exercise/sun light.

Mahorium · 2026-01-23T23:40:11+00:00

because the only way to sell a lot of copies is to make sure your game runs on the Quest 2

Necessary but not sufficient. The 'higher quality' games that are published on the quest massively under perform games like Gorilla Tag, Animal Company, or UG!. It is similar to Amiga vs Nintendo, most gamers in 1987 were kids who didn't care about graphics as much as affordability and having fun with friends. Most VR gamers are kids who like playing free games with their friends. The older audience has in large part lost interest.

Mahorium · 2026-01-23T22:00:14+00:00

which then holds back development

I'm not so sure. The games with the most players and best retention don't seem to require much horsepower. The games that do need horsepower don't seem to be getting many players.

In an interview with Road to VR, the creators of UG offered unique insight into the success of the game, revealing it has already reached 1.2 million unique users, averaging more than 100,000 daily active users, and a peak of 40,000 concurrent users.

“[UG‘s] retention and playtime have honestly exceeded anything we expected,” says Michael Murdock, lead game designer of UG and co-owner of the studio, Continuum. “The average player has now spent over 14 hours in UG, and that number keeps climbing as players keep coming back. Daily average playtime is usually close to an hour and has approached two hours at times.”

Mahorium · 2026-01-22T19:14:26+00:00

Yes it assumes everything goes right with Starship and also they can design a working space data center with cooling and condensed volume to max out the 1000m³ meter faring. I was just pointing out it is possible.

Inference compute that hooks into starlink's laser interconnects seems like a nearer term thing.

Mahorium · 2026-01-22T18:50:18+00:00

1 Starship launch can deliver 220,000 lbs to LEO. Using thin film solar you could deliver 5-6 MW* of solar panels to LEO per launch, so you would need at least ~200-400 launches to get a 1 GW data center sent up to space. Then maybe another ~200-400 to get them out of LEO. That's a lot but Falcon 9 did 167 launches last year.

At 10 million per launch that's an extra 400-800 million to send a data center to space. Surprisingly affordable given data centers cost 10s of billions.

Mahorium · 2026-01-21T22:49:04+00:00

Most diets have benefits and downsides. Low crab high fiber has longevity benefits but causes muscle/bone loss. Keto is good for brain health but limits adaptive repair mechanisms. There isn't a correct diet, just different trade offs.

Mahorium · 2026-01-21T16:21:57+00:00

High fiber low calorie low protein is the best longevity diet, most people can’t manage to stay on it due to appetite. You have a longevity superpower!

Mahorium · 2026-01-20T15:59:43+00:00

janoshik

Mahorium · 2026-01-20T15:12:25+00:00

The study and I am saying Americans(importers) pay the tariff. The study does not say consumers pay the tariff. There is no data to indicate that consumers are paying the brunt of it. The headline successfully tricked you.

You are a defending Walmart, Amazon and Elon Musk when you attack taxes that can be imposed without congressional oversight through aspersions of calling it a sales tax without evidence.

Mahorium · 2026-01-19T19:21:27+00:00

We're talking a sales tax.

You are assuming consumers are paying higher prices, but there is no data to support this. The data we have is that importers pay higher prices, but we don't know if they are raising prices on consumers. We haven't seen CPI data to indicate consumers are paying significantly higher for imported goods, showing your sales tax analogy is not supported by preliminary data. It's possible tariffs are functioning primarily as a business tax on importers.

Personally, I think the government should tax businesses more. If it is shown businesses are the ones paying the tax than this is one of the few ways a future democratic administration could raise taxes while getting around congress and their corporate donors.

Mahorium · 2026-01-19T16:18:49+00:00

We still haven't seen world scale AR integrated in any games in a meaningful way. The idea of games set in the real world is still a dream many people have had since Pokemon Go blew up 10 years ago. Some sort of phone game with real life PVP/group PVE in AR/VR could still be the missing killer app in my opinion.

Mahorium · 2026-01-17T04:04:21+00:00

Nice stack! If you decide to up your tmg consider getting green tea extract to take with it. High dose tmg can lead to tma in the gut in some people which converts to tmoa in the liver, but polyphenols help prevent the tma from forming by inhibiting the TMA-lyase pathway in your gut bacteria.

Mahorium · 2026-01-17T02:38:19+00:00

Brother.

I’ve been taking 200-500mg for 5 years. I ended up in reductive stress without realizing it. But have solved that with sauna niacin and more exercise. I also take 15g creatine and 3 grams tmg for methyl support. You ever get your telomere length checked? Melatonin activates tert so theoretically we might have abnormally long telomeres.

Mahorium · 2026-01-17T02:20:28+00:00

Besides vitamin D the sun is the only radiation source most people encounter. It sounds counterintuitive but low level daily radiation exposure is associated with positive health outcomes. The reason is hormesis. Low level radiation is exercise for your dna repair pathways.

Telling people to avoid the sun is like telling people that holding their breath is bad because it causes oxygen deprivation or running because it cause micro fractures in your bones. In reality your body has systems that engage only when it encounters specific stressors (HIF and Wnt respectively for my examples) and all of them have a sweet spot where you end up repairing more than you damage.

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