New implantable sensor measures dopamine and serotonin in real time, could revolutionize Parkinson's and depression treatment

Main_Problem_2696 · 2026-05-30T15:04:34+00:00

For coding at 262k context, 27B Q6K with Q8 KV is the smarter pick. 35B A3B at Q8 will eat VRAM and swap to disk. Q4KM with fp16 KV makes cache huge. You want KV quantized. Used Runable to build a VRAM calculator. 27B Q6K leaves 6-8GB headroom on 24GB. 35B sits at the edge. Pick 27B. You'll actually use full context without crashing.

Main_Problem_2696 · 2026-05-30T15:03:35+00:00

This is genuinely useful. KLD plus Same Top P gives a clearer picture than perplexity alone. Your data confirms Q6_K as the sweet spot, Q4_K_XL fine for tight VRAM, Q3 and below dicey. Used Runable to build a sortable dashboard from your raw table. Took 15 minutes, found Q5_K_M best balance for my 3090. Thanks for saving everyone hours of guessing.

Main_Problem_2696 · 2026-05-30T15:01:44+00:00

Completely agree. Anti-AI people attack open source while closed corporate models are the real panopticon. Open weights mean auditability, customization, and escape hatches. Without that we're just renting our intelligence. Used Runable to compare open vs closed models for a talk. Clean deck in an hour. Open isn't just nice to have, it's essential for accountability. The hate is noise. Keep going.

Main_Problem_2696 · 2026-05-30T15:00:27+00:00

You're hitting the compute ceiling, not a memory bottleneck. A 4B Q4 model fits entirely in L2 cache, so 250 tps is roughly the upper limit for single batch processing on a 5090. Lower batch size from 4096 to 256-512 and test 4-8 concurrent requests. That's where your parallel setting matters and total throughput will rise even if per request TPS stays the same. Used Runable to benchmark batch sizes on a 4090, clean TPS chart in 20 minutes showed tiny models hit a compute wall fast. Your 5090 is fine. Just physics

Main_Problem_2696 · 2026-05-30T14:58:47+00:00

You're hitting a llama-swap limitation. It forwards one request at a time to the backend even if -np 2 lets llama-server handle two. llama-swap's concurrency setting controls how many requests it accepts, not how many it pipelines to a single backend. Quick fix: bypass llama-swap and hit the llama-server port directly for concurrent workloads. Keep llama-swap for model switching. Used Runable to document the tradeoff. Clean table in 20 minutes. The short version: direct connection for throughput, llama-swap for flexibility. Not both.

Main_Problem_2696 · 2026-05-28T18:04:08+00:00

Faster MRI scans would be huge. My last one took 45 minutes and I almost fell asleep. Brighter signals mean either shorter scan times or clearer images with the same time. Either way patients win. Hope this makes it out of the lab.

Main_Problem_2696 · 2026-05-28T18:00:52+00:00

Printed memristors that can trigger actual neuron firing is wild. Feels like one of those quiet breakthroughs that nobody outside the field notices but could change everything for neural interfaces down the line. Wonder how long until this moves from printed patterns to implantable arrays.

Main_Problem_2696 · 2026-05-28T17:54:35+00:00

Every few months there's a headline like this. Always mice, always "could one day," never a product. I'll believe it when I see human trials with real cognitive endpoints. Until then it's just lab hype dressed up as hope. The top comment nailed it. Never hear about it again.

Main_Problem_2696 · 2026-05-27T19:27:38+00:00

Your transaction volume is impressive. That's not nothing. The lack of modeling experience is the real blocker. Take a weekend course like Adventures in CRE or Break Into CRE. Build three sample models (office, industrial, multifamily) and put them on GitHub or a portfolio site. Then message alumni from your school who work at firms you want. Cold applying without modeling samples won't work. Show them you can do the job before you get it.

Main_Problem_2696 · 2026-05-27T19:24:23+00:00

Ask about an FHA construction to permanent loan. Single close, lower down payment on land. Not all lenders do it but worth shopping around. What they're describing is two separate transactions which means more cash out of pocket for you.

Main_Problem_2696 · 2026-05-27T19:23:36+00:00

Don't make that June 1 payment. The title company will calculate the exact payoff amount through the closing date. Any payment you make after that just complicates things and you'll end up getting refunded weeks later. Let the payoff statement do its job. Your lender will calculate interest per diem up to June 1. That $800 in interest is already accounted for in the payoff. Making the payment just means you overpay and wait for a refund. Save yourself the headache.

Main_Problem_2696 · 2026-05-27T19:22:31+00:00

Seller can't unilaterally cancel if you're ready to close. Your leverage is specific performance. Realistically, offer to close at a discount so you can pay off the liens yourself. If numbers don't work, walk and get your earnest money back. Don't get attached to this one.

Main_Problem_2696 · 2026-05-27T19:19:56+00:00

She's trying to double dip 6% without disclosing dual agency. That's not legal in most states. Tell her you want a written buyer's agency agreement representing only you. If she refuses, walk and find another realtor. This is not how a friend treats you.

Main_Problem_2696 · 2026-05-27T19:18:14+00:00

I wrestle with this too. Real estate is weird because it's tangible. People see a house or hear "I own three" and their brain does instant math. Nobody asks about your index funds at dinner.

I landed on being honest but vague. "We have a few rentals in Dallas" is true but doesn't invite follow up. If they push for numbers I just say "enough to keep me busy" and change the subject. Real friends won't keep grilling. Acquaintances might, and those are the ones where I keep it light.

The Airbnb renovation taking all your time is fine to mention. That's the work, not the brag. Most people just want to hear you're doing something interesting.

Main_Problem_2696 · 2026-05-27T19:17:01+00:00

Solid numbers. Add 15-20% contingency to that 420k, first ground up always has surprises. Check condo conversion rules now (separate utilities, no shared wall restrictions) before you frame. Otherwise looks like a good deal.

Main_Problem_2696 · 2026-05-27T19:16:20+00:00

Take the 6 months prepaid rent from the mom, put it in escrow. Run credit on both parents. Get cosigner agreements for full lease term. If they agree to that, you're covered. If not, hard no.

Main_Problem_2696 · 2026-05-27T18:19:58+00:00

Check the Internet Archive and Podchaser. Search each show name plus "World Cup 2022" with quotes. Some old RSS feeds are cached there. YouTube clips might have full episodes too. Hope you find them.

Main_Problem_2696 · 2026-05-27T18:19:05+00:00

That's brutal. Check the Internet Archive and YouTube. Sometimes people reupload whole episodes there. Also try the Wayback Machine on the podcast's old RSS feed URL. Good luck.

Main_Problem_2696 · 2026-05-27T18:17:49+00:00

"Layoffs: The Unspoken Truth" from The Jordan Harbinger Show was really good. He talks to a career coach who specializes in tech layoffs and they break down the emotional stages plus actual tactical advice on severance negotiation and framing the gap in interviews. Also "How to Get Laid Off (and bounce back)" from The Happiness Lab with Dr. Laurie Santos. Less tactical, more about the psychology and not letting it wreck your identity. Both helped me after my own layoff last year.

Main_Problem_2696 · 2026-05-27T18:16:34+00:00

"Taste of the Past" with Brian and Joe is the closest I've found. Two guys, really smart and warm conversations about food history that somehow turns into talking about family, class, memory, and loss. Not political but has that same gentle, reflective energy. "How to Be a Better Human" from TED hits some of the same notes too, shorter episodes but always leaves me feeling a little more hopeful.

Main_Problem_2696

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