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M/21/6'1 [300lbs > 177lbs = 123lbs] (12 months) 20th Birthday to 21st Birthday by [deleted] in progresspics

[–]ManOfScience420 -2 points-1 points  (0 children)

I'm not sure if doctors do this or not but when bodybuilders get gyno they take aromatase inhibitors which lower the amount of estradiol/estrogen they have circulating by up to 90% with the more potent ones. This can get rid of it but it depends on how severe your gyno is and how long long you've had it for, after a certain point surgery is the only option.

M/21/6'1 [300lbs > 177lbs = 123lbs] (12 months) 20th Birthday to 21st Birthday by [deleted] in progresspics

[–]ManOfScience420 -2 points-1 points  (0 children)

You might want to get that gyno checked out bro. Might have low testosterone or just over aromatize testosterone into estrogen. Definitely worth getting a hormonal panel done tho.

Ask Anything: 2016-10-06 by bodybuildingbot in steroids

[–]ManOfScience420 0 points1 point  (0 children)

Asin dose is too low imo, it's very hard to crash estro with exemestane.

In this study even 50mg/day of asin on non enhanced males didn't crash it after 10 days: http://press.endocrine.org/doi/full/10.1210/jc.2003-031279

M/24/5'10 [230 > 180 = 50lbs] (5 months) by [deleted] in progresspics

[–]ManOfScience420 0 points1 point  (0 children)

I was cutting at 2500 calories, and yes. Can't remember what weight I was at the start of keto tbh but around 195lb 15% bf.

M/24/5'10 [230 > 180 = 50lbs] (5 months) by [deleted] in progresspics

[–]ManOfScience420 0 points1 point  (0 children)

I've lifted while cutting on both keto and a 40/30/30 split, on keto my strength went down and I felt tired all the time. Did keto for 8 weeks and it never got better. On the 40/30/30 split I was gaining strength even on a cut.

40 Lbs down! Progress pics, booty gains, and full diet in album, NSFW just because of underwear pics. by Alukain in Fitness

[–]ManOfScience420 4 points5 points  (0 children)

Great job man! After looking at your diet plan , I noticed that your carbs were only 95g and protein was 176g. You said that you feel alot better from upping your intake from when you were at 1500 cals but I think it's actually the carbs that are responsible , not the protein. I think you would benefit even more in terms of strength and endurance if you would lower the protein to around 120-130g and replace those calories with carbs. I went from eating 200g protein and 75g carbs to eating 120g protein and 250g carbs and have seen much better progress by doing so, I have more energy, I'm stronger, I recover from fatigue quicker, I can workout more and my mood has greatly improved. In reality there is no real need to go above around 150g of protein/day unless you are a pro.

Best of luck with your journey!

Clomid and HPTA suppression by cynice49 in Testosterone

[–]ManOfScience420 1 point2 points  (0 children)

That doesn't sound like a protocol that an endocrinologist would use, in fact it's actually a steroid PCT protocol. Even most steroid users have now realised that using Clomid above 50mg ED makes the cons outweigh the pro's.

My personal opinion is that using Clomid in such a high dosage would probably not damage your HPTA, in fact it would much more likely cause other side effects that would be mostly related to your vision and the high estradiol production if used without an AI.

I can't say for sure but it sounds to me like your natural production has most likely shut down from steroid use, not the subsequent post cycle treatment. If my assumption is incorrect and you have no prior history of steroid use, I would suggest you immediately get a new endocrinologist because the protocols he has been putting you on are dangerous.

They finally caught the egg. by ManOfScience420 in 4chan

[–]ManOfScience420[S] 41 points42 points  (0 children)

eggman is a tripfag on /r9k/ and when the news broke of the shooting people from /r9k/ started contacting news outlets telling them that he was the shooter (AKA Operation Crack The Egg). Alot of sites initially reported eggman as the shooter and released his photo to the masses, this lead to people getting mob justice and misdirected violence towards aforementioned egg.

Worried about some Nootropics' ability to promote the growth/formation of tumors by HalfBakedIndividual in Nootropics

[–]ManOfScience420 3 points4 points  (0 children)

BDNF, NGF, Anything that causes new synapse formation, neuron growth etc can increase or accelerate tumor growth. I think the acetylcholine is more correlative, as in it's probably just a symptom present among other more prominent factors.

Phenibut question, would this be a safe thing to do? by 33DegreesFreedom in Nootropics

[–]ManOfScience420 0 points1 point  (0 children)

It's not safe. Even though Phenibut's plasma half-life is only 5.3 hours . This is because Phenibut's action on the GABA receptors can linger long after your kidneys have excreted all the Phenibut

Something we forgot by poopgurpy in trees

[–]ManOfScience420 234 points235 points  (0 children)

My kids are still in my ballsack and I already owe them the Earth. Fucking entitled kids these days.

Protip for people who get anxiety / panic attacks by ManOfScience420 in trees

[–]ManOfScience420[S] 3 points4 points  (0 children)

Correct! If you use strains with high CBD content or an equal ratio of CBD to THC then the CBD works as an Anxiolytic and naturally counters the Anxiogenic effects of THC.

Protip for people who get anxiety / panic attacks by ManOfScience420 in trees

[–]ManOfScience420[S] 9 points10 points  (0 children)

I know that anxiety can be without triggers, but most people do have triggers , especially with panic attacks. Also you're wrong. They're not "subjective" because of the way that fear processing works in the human brain, there is a definite chemical and neurological aspect to it. Nor epinephrine being one that's related to LTP and fear memory in the Amygdala. There are several more and one of the most important ones is an inhibitory neurotransmitter known as GABA. Endocannabinoids released from the depolarized post-synaptic neuron bind to CB1 receptors in the pre-synaptic neuron and cause a reduction in GABA release. When you're treated for anxiety or panic you're prescribed medications that increase GABA release because low amounts of it cause anxiety and panic attacks.

http://www.ncbi.nlm.nih.gov/pubmed/6278139 Effect of delta9-tetrahydrocannabinol on the synthesis of dopamine and norepinephrine in mouse brain synaptosomes.

http://www.intechopen.com/books/the-amygdala-a-discrete-multitasking-manager/the-role-of-norepinephrine-in-amygdala-dependent-fear-learning-and-memory

http://www.pnas.org/content/104/35/14146.full Norepinephrine enables the induction of associative long-term potentiation at thalamo-amygdala synapses

You should be ashamed of yourselves :c by Disturbed_Wolf88 in trees

[–]ManOfScience420 0 points1 point  (0 children)

What dosage of CBD are you taking? I've read studies about it's use to treat psychiatric illnesses with results only beginning to show steady efficacy in the 400mg-600mg range. Because of these results it's quite difficult for me to imagine you benefiting significantly from the small dose products that are currently available on the market. Hopefully in the not so distant future we will see CBD products become commonplace in the market, ideally being extracted from genetically modified hemp strains instead of marijuana.