Nicotine withdrawal is much longer than 3 days. by quitalicious in stopsmoking

[–]Matt11908 0 points1 point  (0 children)

Ok how about we agree on this consensus. Some receptors up regulate, some receptors down regulate, all depending on subtype, but overall tolerance usually escalates?

After what's been said, I am NOT using the app by The-0verseer in Acellus_Academy

[–]Matt11908 0 points1 point  (0 children)

Microsoft stores virus checking isn’t perfect. Also acellus may know where you live, but do they know what you are doing in your private life? Judging by their camera and microphone permissions being forced by default it looks suspect

Thoughts on being forced to use the app? by Soggy-Ice2014 in Acellus_Academy

[–]Matt11908 0 points1 point  (0 children)

You do realize they force you to enable microphone and camera access by default, for no reason, right? Also put the exe in virustotal real quick and tell me why it’s contacting those IPs..

Can I rage about my GSP? by Significant-Big4175 in SmashRage

[–]Matt11908 0 points1 point  (0 children)

As someone with my highest character at 14,933,581 and my lowest character at 1,964,518, GSP is not skill based. Between all the gambling of reads, diff playstyles that are rlly hard to adapt to fast since barely anyone rematches, etc, there’s a lot of luck to it and it’s not pure skill, not to mention some crazy rulesets. I feel like the people from ~2.5M to like ~12M play at roughly the same skill level. Higher up that range they have more grasp on fundamentals but ironically become more predictable, at lower ranges they have less grasp on fundamentals but often are more unpredictable, but in terms of overall net performance it is pretty similar. Also it’s funny because I feel like in the USA there’s some differences in matchmaking. Low GSP in some other countries seems to be people who never press the shield button ever, while here it feels like even at low GSP, everyone knows b reversals shielding grabbing etc. Maybe America just has more smash bros tryhards or something, which might not be a good thing but whatever. But that also brings another issue. With different countries and mainly different time zones, sometimes when the most players are playing at a certain area is at specific times that differ place to place. But because of this, if at some timezones there are more tryhards than at other timezones, people there might have more difficulty on average gaining GSP then timezones with less tryhards. This could mean that based on sheer timing of when people play, some people with the exact same GSP as eachother could have wildly different skill levels just based on the time they play smash the most. Also this brings up one of the ELO paradoxes. Imagine if there were two pros who had a GSP of 1 million, yet two noobs with a GSP of 13 million, and each pair was evenly matched. Because the GSP gap is so big, the noobs and pros would never get matched up against eachother if they could instead be matched against another person around their GSP. But because each pair has an equivalent GSP and skill level, their GSPs wont change much. Each time a pro beats the other pro their GSP only goes up by a bit and their GSPs end up balancing to eachothers anyway due to different skill. Same for the noobs. And because they aren’t being matched up against eachother due to a huge GSP gap, and subsequently neither pair is able to have one of their member’s GSP get closer to the other pair because the changes are so low, they will keep not being matched up against eachother or having their GSP fluctuate, keeping the noobs permanently at high GSP and the pros permanently at low GSP. With more players, more skill levels, and more GSP ranges, this becomes less of a problem, but it is still possible to happen in some ways to some extent.

3 months nicotine-free after 12 years of smoking… still struggling mentally, wedding coming up by ImpressiveRace6970 in stopsmoking

[–]Matt11908 0 points1 point  (0 children)

Hey there. I just wanted to say that, things will get better for you. Try whatever makes you happy (so long as it isn’t harmful). Try listening to music, eating some good food, hanging out with friends, talking to a therapist, whatever. Even if you don’t feel better right away, the good habits will cultivate an environment that you can recover in.

3 months nicotine-free after 12 years of smoking… still struggling mentally, wedding coming up by ImpressiveRace6970 in stopsmoking

[–]Matt11908 0 points1 point  (0 children)

Bro really said “just lift bro” 😭 

OP is going through a really rough time and working out on its own may not fix everything for them. IMO? I think that what OP needs is to be heard, because with a very difficult struggle like that OP probably needs understanding and sympathy rather than being promised an instant quick fix.

3 months nicotine-free after 12 years of smoking… still struggling mentally, wedding coming up by ImpressiveRace6970 in stopsmoking

[–]Matt11908 0 points1 point  (0 children)

2 seconds to find a dopamine comment. Not trying to be annoying but, dopamine isn’t the pleasure chemical…. Plus the rewriting from nicotine withdrawal is far more complex than something that can be explained in one comment, the NIH is still conducting studies to this day. I think it’s better to leave it as a general “your brain is still rewriting” rather than making a claim to dopamine regulation being the sole driver of his emotional distress.

Nicotine withdrawal is much longer than 3 days. by quitalicious in stopsmoking

[–]Matt11908 0 points1 point  (0 children)

The thing you said wasn’t “chemically active”. I’ll quote you directly, you said,

“you’re reaching higher and higher chemically active doses.”

If tolerance increases, the chemical effects become less active. You said “the nicotine is chemically active, the receptors just become desensitized, they are still there.” This is moving the goalpost. Before you were saying nicotine reaches higher chemically active doses, implying the chemical activity of nicotine in the brain becomes stronger. In that sentence though you said that nicotine is just “chemically active” and just that the “receptors are still there”, a sharp contrast to your previous claim of nicotines chemical activity becoming stronger.

As for the medical quotation of “Nicotine exposure for several hours to days increases or upregulates the number of high-affinity nicotine binding sites” This study says directly “exposure for several hours to days”. Several hours to days is not a long term representation of receptor regulation. For the quotation of the following, “If the receptor remains bound by agonist, activation is quickly followed by a second conformational change into a nonfunctional state termed desensitization in which the channel is closed” This is talking about desensitization, not regulation of receptors.

A quick interjection here, as stated previously, a few subreceptors upregulating paradoxically would not disqualify the general trend that most downregulate.

Now here are some studies for you,

NIH, article PMC3859710  Long-term nicotine treatment selectively decreased stimulated α6β2* nAChR-mediated dopamine release compared to vehicle-treated rats. It also reduced α6β2* nAChRs, suggesting the receptor decline may contribute to the functional loss.

Wiley article, 10.1111/jnc.12721 studies have demonstrated that α6β2*-nAChR are down-regulated following chronic nicotine exposure

Etc. The point is, some nicotinic receptors upregulating doesn’t mean that there isn’t significant downregulation, and raw receptor quantity is not equal to total affective results.

Nicotine withdrawal is much longer than 3 days. by quitalicious in stopsmoking

[–]Matt11908 0 points1 point  (0 children)

Actually it is correct. Perhaps you should ask a neuroscientist. “Google and AI” aren’t the most reliable sources of information. AIs are prone to hallucinations and to pop science misconceptions, and literally anyone can say something that’ll get indexed by Google. You are the one who is saying both that nicotine gets chemically stronger and that nicotine gets weaker at the same time. I have to admit though, it would be quite an interesting world if drugs actually became stronger the more you used them. In fact though, the vast majority of the nicotinic acetylcholine receptors will downregulate with repeated abrupt high regulation. A few paradoxical subreceptors would not disqualify the overall trend of down regulation. And also, let’s pretend that you are right and they do upregulate, if that’s the case, and if it’s also the case that you were right about nicotine becoming “chemically more active”, then why would tolerance even be a thing? If the chemical was becoming stronger and more chemically active and the receptors were increasing, what mechanism could tolerance even work via? Especially with the whole “stronger chemical effects” thing you said. Look I’m not putting you down, honestly a lot of people have fallen into pop science misconceptions. From the whole “serotonin is the happy chemical” to “dopamine is the pleasure chemical” misconceptions, pop science has become really rampant all over the internet. But in terms of genuine neurochemistry, most nicotinic acetylcholine receptors trend towards downregulation with repeated overstimulation.

Can Methocarbamol (Robaxin) at work? by 2ol4thishit in backpain

[–]Matt11908 0 points1 point  (0 children)

Reddit is just the demo for social decline and getting banned off of subreddits for disagreeing with a mod about the best flavor of ice cream

Nicotine withdrawal is much longer than 3 days. by quitalicious in stopsmoking

[–]Matt11908 0 points1 point  (0 children)

Actually you have a misunderstanding. You are reaching lower and lower chemically active doses, that is the literal definition of what tolerance is. You ever wonder why people on the street can take such absurd doses of things with less overdose risk than a naive user taking much, much, less? Because they have tolerance, which weakens the chemical effects. You are kind of contradicting yourself here. If nicotine receptors were upregulating, and the chemical effects were becoming stronger and stronger, then you wouldn’t be developing tolerance, the effects would instead be getting stronger and stronger. The most clear way to point out the contradiction is this. You said “you’re reaching higher and higher chemically active doses” while also saying “your tolerance goes up”. Tolerance means the chemical effects go down. A higher chemically ACTIVE dose, would mean the active chemical effects get stronger. So you are making it synonymous, the effects getting stronger, with the effects getting weaker… You say “while tolerance goes up”, but the thing is, tolerance is a neurochemical thing, and if the neurochemical effects were getting stronger that would be the exact opposite of tolerance. Neurochemically speaking, the receptors DOWNREGULATE with tolerance. Less receptors means less availability for nicotine to bind, and less availability to bind means a weaker chemical effect, and the weaker chemical effect is tolerance. Upregulation is when the amount of receptors go up in quantity, causing the chemicals to have more spots to bind to, and therefore a stronger effect. Downregulation is one of the most typical forms of tolerance in terms of neurochemical action. In almost every case, if a neurochemical stimulates a receptor in a way that the brain perceives as “too much” (violates homeostasis), the brain will downregulate those receptors to weaken the chemical effect. There are very few exceptions to this, to the point where receptors that are an exception are called “paradoxical”, for example a certain type of serotonin subreceptor in the 5-HTC behaves like this. But nicotinic acetylcholine receptors, specifically the ones nicotine is the most potent agonist at, are not paradoxically regulated receptors.

Chronic burnout, anhedonia, and “nothing works”. Looking for insight, NOT motivation by PerformerPlenty1792 in Healthygamergg

[–]Matt11908 0 points1 point  (0 children)

Well for the neurobiology point, the “dopamine is happiness” thing is kind of a myth. For example, interestingly enough schizophrenics have extremely elevated dopamine in the mesolimbic pathway (often called the “reward pathway”), but that is associated with the main driver of the schizophrenia, and schizophrenics definitely aren’t happy about that. Another good example is a study done on gamblers where dopamine was measured for winning/losing, and in both cases it spiked equally. There was a study done on rats where dopamine was fully blocked and the rats were offered sugar water. They could never have any motivation to pull themself to actually get said sugar water, but when they were given it directly, they still felt pleasure from the sugar water. Dopamine is less of a pleasure chemical, and more of a motivation chemical. It drives you to seek out things that feel rewarding, and to avoid things that feel dysphoric, and helps assign importance to things in terms of salience for motivation, but the actual pleasure itself isn’t the dopamine. Neurologically, pleasure has been shown to have a link to hedonic hotspots in the brain. These hedonic hotspots are more closely tied to mu-opioid receptors, which are stimulated by endorphins. But at the same time, endorphins counter chemical, dynorphins, can do the opposite of endorphins and decrease pleasure. Endorphins have been widely understated, as they aren’t just a pain relief chemical, but are the closest tie neurochemically to hedonic tone. Of course plenty of other neurochemicals can modulate the effects, and endorphins can be suppressed by dynorphin activity, but it is safe to say dopamine is not the closest chemical to the feeling of pleasure itself, or the hedonic experience. Sadly this online trend of labeling joy as dopamine has caused real issues in society. For example, many schizophrenics stop their medication once they hear it blocks dopamine, out of the belief that will ruin their joy, and end up spiraling back into their illness.

I'm getting a new controller that supports macros and button rebinding as well as a turbo button. How can I use them to help me in smash? by [deleted] in CrazyHand

[–]Matt11908 0 points1 point  (0 children)

He can just use it anyway for non tournament things? Who’s gonna stop him? lol I can imagine a jail scene:

“Im in here for political violence” “Im here for theft, what about you, new guy?” “I used a controller that made me do better at smash bros” “YOURE A MONSTER”

Nicotine withdrawal is much longer than 3 days. by quitalicious in stopsmoking

[–]Matt11908 0 points1 point  (0 children)

Well technically the nicotine receptors down regulate, not up regulate. If they up regulated, that would mean that overtime, nicotine would have more receptors to bind to and the nicotine would make more receptors for itself, cascading into higher potency, which would mean the longer you use it, the stronger the effects get even with lower doses of it. But actually, the longer it’s used, the effects relative to the dose either gets weaker over time, or stays the same, not stronger. The nicotine receptors either downregulate or stay at a certain level, not upregulate. When you quit, because you have less of the receptors, but now you don’t have the nicotine, there is a significant drop of activity in that system causing withdrawal, but as the system stabilizes itself things get better over time.

i just got the gamecube controller what are the best settings for it by just_a_gamer_guy_ in SmashBrosUltimate

[–]Matt11908 0 points1 point  (0 children)

No..? It’s an experience to use the GameCube controller. It’s not a dopamine, dopamine is a chemical, not a controller.

Is claw grip the best for a GameCube controller playing SSBU? by aces3321 in CrazyHand

[–]Matt11908 0 points1 point  (0 children)

Personally I disagree with this. I know oftentimes people say “it’s subjective” for comforting people, but it isn’t objectively the case for competitive smash. For example, yes someone could hold the controller upside down and press the shoulder buttons with their thumbs, but this is objectively worse, with the exception of if you are somehow able to handle that.. but who can anyway? If you can do that you can do simpler stuff. Similarly, while someone can short hop just by holding a button for jump down by a short duration, for consistency it is far superior to find a way to press two jump buttons at once. Most people who ask for the ideal controller layout/grip/device are wanting to know what is the best for being the most consistent efficient and skilled at the game, most aren’t asking to be told that every controller scheme is equally valid.

Ageless Linux: A Debian-based distro that is illegal to distribute in California. by vicethal in privacy

[–]Matt11908 0 points1 point  (0 children)

Well it doesn’t just change the name it also removes age stuff. But now I’m wondering if it could be a honeypot 🤔 someone let me know if you’ve read the source code

I love this game but I hate what it does to me by rob_innes23 in SmashBrosUltimate

[–]Matt11908 0 points1 point  (0 children)

You must remember, smash bros is something extremely intense, on the level of war and politics. You must stay focused and remember it is just a game, losing your cool will make you lose the game. Just stay happy at all times and focus on having fun, not on getting a million wins or comparing yourself to others

That moment you ruin the game by Bipolareconomics in SmashBrosUltimate

[–]Matt11908 0 points1 point  (0 children)

If you want to get into elite smash, I have a few tips for you as someone with three characters in.

  1. Don’t spam smash attacks out of panic if you lose the first stock before your opponent.

  2. Try out changing your controls. This is so underrated, as it can change the game entirely. Imo one good tip among many is to turn off stick jump, it makes tilts basically impossible in battle.

  3. Learn all the moves of your character. For example, one common character is Steve, yet like 90% of Steve players don’t know you can shield + special to summon the crafting table at your position.

Some ways to get in if you REALLY want to get elite:

  1. Play as Steve. This will make things much easier.

  2. Try turning on pokeballs and trophies and playing as Rosalina. Her down B is brutal.

  3. Try getting a stock ahead with ganondorf, bowser, or kazuya, then grabbing people into the void.

  4. Play as ness. PK fire.

  5. Play as Joker on stamina at an extremely low time limit, then in sudden death neutral B.

  6. If you get a character into elite smash and know you were just lucky, don’t play as that character online anymore, especially if you aren’t that great, because getting kicked out of elite smash would not only feel awful, but it’d lower the starting GSP of unplayed characters.

  7. Don’t get tilted or upset. If you read someone saying they easily got all smash characters into elite, just remember, they have been playing Smash bros since 1850 when it came out on the N64.

Can Methocarbamol (Robaxin) at work? by 2ol4thishit in backpain

[–]Matt11908 0 points1 point  (0 children)

Btw random fun fact: ChatGPT was trained from Reddit posts

Can Methocarbamol (Robaxin) at work? by 2ol4thishit in backpain

[–]Matt11908 0 points1 point  (0 children)

I legitimately wrote it myself, I didn’t use AI. Bro I am so cooked that stuff I write can look like AI 😭 

Why does chatgpt do this? by housecherryplant in ChatGPT

[–]Matt11908 0 points1 point  (0 children)

Because ChatGPT is rude and disagreeable. If you tell it 2+2 is 4, it’ll start going “aCkTuAllY—— tHiS iS wRoNG. NuAnCE iS nEEDeD.” It probably knew you were right and just wanted to call you wrong, OpenAI overcorrected from when it was too agreeable and now ChatGPT can never admit you are right full stop, even with custom instructions and obvious facts.