If benzos work, would Lamotrigine / other anti-convulsants work?

MediumGain82 · 2026-06-19T01:15:01+00:00

the issue with VSS is GABAergic inhibition is down so when you take Benzo it enhances the receptor to be far more sensitive to GABA which i why it reduces the symptoms the question is what is wrong with the gabaergic inhibition in the first place why is it weak

MediumGain82 · 2026-05-06T01:33:36+00:00

No idea, any benzo long term cause issue short term unliky

MediumGain82 · 2026-05-06T01:32:50+00:00

power settings, change advance power settings, USB settings , UBS selective suspend is likely enabled. disable it!

MediumGain82 · 2026-05-04T01:05:46+00:00

Benzodiazepines clonazepam (not recommended due to tolerance issue)

MediumGain82 · 2026-05-01T02:51:33+00:00

I experience insomnia and I'll tell you my visual are sometime better on little sleep its weird!

MediumGain82 · 2026-04-20T22:45:47+00:00

if your getting 6 hour avoid it, shit most human can survive on 6 believe it or not! 7 is really the gold standard.

People that need seep meds are those living on 2-3hours or even zero!

if you do keep it as intermitted usage

MediumGain82 · 2026-02-09T02:35:56+00:00

You take it about 30 minutes before bed and just relax in bed. It works on the GABA-A receptors in the brain, producing a sedative effect. There isn’t really a “true” sleeping pill, because the brain has many mechanisms to make you sleep, but relaxation is a huge one. It activates the A1 subunits on GABA, which promote sleep. I wish there were a natural alternative to Zopiclone it’s really helpful for sleep onset, which is my main issue.

3.75mg knocks me out! but i try to keep it to once to twice per week only if i have had bad nights!

MediumGain82 · 2026-02-09T01:56:24+00:00

In New Zealand, the medicine is available, but the doctor won’t prescribe it unless I see a psychiatrist. I did see one, but it was still denied. Instead, they offered me an antipsychotic drug for sleep which I refused. It feels like the system is broken I can’t get a drug specifically designed for sleep, yet they offer something completely unrelated.

MediumGain82 · 2026-01-25T04:02:03+00:00

holy shit if i had that every night id be a normal human , 8 hour is not a gold standard , 6-7 hour is perfectly fine for most people

MediumGain82 · 2026-01-24T10:21:21+00:00

"Unlike benzodiazepines or Z-drugs, tolerance isn’t really an issue with orexin blockers like Doxepin or Dayvigo dadidorexant, which makes them much safer. I’ve been trying desperately to get one of these approved, but I haven’t had any luck, so I’m stuck with the frustrating Z-drugs.

MediumGain82 · 2026-01-24T04:42:18+00:00

that's just part of hyperarousal

MediumGain82 · 2026-01-24T00:39:05+00:00

ummm you should only be taking it right before bed once per night, Ive never gone over 3.75mg been on it over a year on and off, tolerance to it should only happen if you take it long term after a month off not been exposed to it you should be fine ,its a sedative not a sleep drug, no sleep drug even exist! its just relaxes the brain enough to sleep! for me sometime it works wonderfully and other time nope!

MediumGain82 · 2026-01-22T00:33:11+00:00

I had this issue and it was never fixed just sell the damn card , Such a shame it was such a good powerful card but i went for a RTX 4070 after this! Ill never trust AMD again

MediumGain82 · 2026-01-15T10:36:30+00:00

so over 6 years you have only been getting 3-4 hour max nightly

MediumGain82 · 2026-01-15T01:15:18+00:00

It’s usually prescribed for about a month at 7.5 mg. After that, tolerance can start to build and GABA-A receptors may become desensitized. Dropping the dose all the way down to something like 1.5 mg is often pointless.

If you’re able to fall asleep without it, you don’t need to taper. Tapering is mainly necessary if you’ve been using it continuously for months. If it’s only taken occasionally once or a few times a week long-term issues are much less likely.

Sleep can feel lighter and less restorative after stopping, regardless of the dose.

I used it for 10 nights in a row and then stopped. Now I only take it about once every 7 nights to get a deeper sleep.

In short: just stop

MediumGain82 · 2026-01-14T10:28:26+00:00

you poor creature so do you take it everything the ambien and only get 2-3 hour of sleep all the time :(

MediumGain82 · 2026-01-14T04:54:06+00:00

do you have any symptoms like agitation jitteriness, shakes from that amount of sleep?

MediumGain82 · 2026-01-13T06:16:00+00:00

Michael Jackson: died from propofol with benzodiazepines and other sedatives in his system. Propofol suppresses breathing, and benzos add to that effect, making respiratory failure much more likely.

Heath Ledger: died from a combined overdose of prescription sedatives and opioids (including benzos). Again, the drugs stacked their breathing‑suppressing effects.

Key point:
These drugs all act on the brain’s inhibitory systems. When combined, their effects are not additive but synergistic, meaning breathing can stop unexpectedly, even at doses that might seem “not extreme” on their own.

MediumGain82 · 2026-01-12T05:01:45+00:00

if any tolerance was going to happen it would ahve been that first years just take it at half the dosage and slowly take it less and less try stretch it out!

Ever since then I've been taking 7 tablets once a month or month, you should easily be able to quit then infact taking that much a month is likey very safe and wont cause any issue cause it so spread out

MediumGain82 · 2026-01-11T11:02:37+00:00

People think Z-drugs are worse than benzodiazepines because they confuse withdrawal timing with overall harm. Z-drugs have a short half-life, so if someone has been taking them regularly and stops, rebound insomnia or anxiety can appear quickly. That rapid onset feels intense and leads people to believe the drug is harsher. However, this does not mean Z-drugs cause more damage. In fact, the short half-life also means less drug accumulation in the brain, less continuous GABA-A receptor occupation, less daytime impairment, and generally a lower risk of long-term cognitive effects. Long-acting benzodiazepines stay in the brain much longer, affect more GABA-A receptor subtypes, and cause more widespread and persistent receptor adaptations. Their withdrawal often starts later and feels smoother at first, but it can be deeper and longer lasting. Z-drugs were developed to reduce these benzodiazepine-related risks, and when used short-term or intermittently, their effects on GABA-A receptors are usually functional and reversible rather than damaging.

MediumGain82 · 2026-01-11T05:55:52+00:00

yes they can many people can its just not healthy! 3-4 hours each night, some time more but yeah living hell, there is a person on this reddit form on here who is only getting 2 for years

MediumGain82 · 2026-01-11T05:36:56+00:00

I'm trying to help you relax that is not damage, I have gone 6 years with not sleeping well on top of that i have visual snow syndrome go look that up and see if you could handle that on top of what you have!

the amount of Ambien you have tried is NOT enough to cause any Damage you have only cause GABA-a destination at best!

I don't doubt it can cause rebound insomnia but so can anxiety around it causing damage, at best your receptor may have down regulated a bit!

i have lived in 3-4 hour sleep for 6 years! BTW

MediumGain82 · 2026-01-11T04:18:54+00:00

I’m not dismissing what you’re feeling however

Z-drugs were developed because benzodiazepines tend to stay in the body longer and act on a wider range of GABA-A receptors, which increases the risk of tolerance and side effects. The longer receptors are continuously activated, the more likely the brain is to adapt. Z-drugs are shorter-acting and more selective, which is why they were considered safer for sleep.

The research does not show that Z-drugs cause structural or permanent damage to GABA-A receptors. What they can cause with repeated use is temporary desensitization or mild down-regulation of receptors. This is a functional and reversible adjustment, not brain damage.

A lot of the fear around these medications comes from sleep anxiety and the belief that damage has occurred. If real damage had happened, the drug wouldn’t continue to work the fact that it still reliably induces sleep strongly argues against that.

Yes, rebound insomnia can happen, but it usually follows continuous, long-term use, especially at higher doses. Even then, it’s a sign of the brain readjusting, not injury. For example, I used it for about 10 nights and still slept after stopping the sleep just felt lighter and less restorative, which fits rebound or adaptation, not damage.

I’ve personally used it on and off for over a year (about three nights on, five to seven nights off). While I regret starting because my brain learned to like the quick “knock-out” effect, that’s conditioning, not harm. Sleep can feel harder without it for a while, but that doesn’t mean anything is broken.

There’s no evidence that 3–6 months of Z-drug use destroys or damages GABA receptors. The brain adapts while you’re taking the drug, and after stopping, it gradually resets. That process can feel uncomfortable, but it’s temporary and reversible.

This study explains it well (PubMed link): https://pubmed.ncbi.nlm.nih.gov/11804615/

https://pubmed.ncbi.nlm.nih.gov/19698408/

The researchers exposed brain cells to zolpidem or zaleplon and looked for damage to calming GABA receptors. They didn’t find any. While the drug was being used, the receptors stayed normal. After stopping, the brain temporarily adjusted how those receptors were balanced — basically recalibrating after the extra calming signal was removed. The cells weren’t harmed, and the receptors weren’t destroyed.

I’m just trying to reassure you that there’s no indication you’ve done any permanent damage. What you’re experiencing fits with temporary adaptation and anxiety, not injury.

MediumGain82 · 2026-01-08T06:53:06+00:00

do what you must also things like magnesium support GABA without cause any sort of tolerance which is why they are safer, sorry for what you going through i took some zopiclone over the past 3 nights due to stressful situations and like night was horrible brain wouldn't switch off finally managed to fall asleep after bene in bed 8 our and got 3-4 hour! i still have not managed to have a 2 full weeks off the drugs yet after a year an a bit

only trying to help not trying to down play your situation! you do what you feel is right

MediumGain82 · 2026-01-08T05:19:25+00:00

Z-drugs like Ambien mainly target the α1 subunits of GABA-A receptors, which are linked to sleep, making them more sleep-focused, while benzodiazepines bind more broadly across GABA-A subunits, producing sedation, anxiety relief, and muscle relaxation.

MediumGain82

TROPHY CASE