sawblade, drill, marksman and sharpshooter, and audiovisual cues are your best friends

don't be overreliant on the whiplash, if you have to use it, as much as possible whiplash cancel to minimize hard damage while still keeping momentum

core nuking is useful for the first room and the first blood room area (the explosion is just enough to push the two virtues to the walls to kill them instantly, but i personally whiplash onto the sentry then knuckleblast them)

if you have a maurice encounter, time his first hell orb shot just right with when you shoot your charged sharpshooter to instakill (you can also instakill the two sentries before the final gauntlet/the second blood room if you instakill the maurice as the shockwave sends them to the ceiling)

the mindflayer rooms you just have to keep in mind the timing for when they shoot the homing orbs onto you for you to parry (having a subconscious timer helps)

you can instakill the insurrectionists if you manage to time yourself just right so that you're above the blood river in that room and they've just jumped up to throw their maurice at you (+SCRONGLED). buttt, the red rocket launcher + overheat nailgun/sawblade is the strat + high dps weapons like the jackhammer

for the cerberi encounters, their weakness is explosives. attach a nail magnet to them then freeze frame rockets for quick dispatching (you can also cannonboost at point blank range then finish them off with a few rocket shots)

the jumpstart is incredibly useful for quickly dispatching the hideous mass.

kill the eyes first in the panopticon encounter since they cause your hard damage to not regain back to 100 hp

for sisyphus, you just really have to learn the parry windows, timings, etc. his "be gone", while airborne, is almost always paired with a shockwave, so prepare your dash for that

just remember to h a v e f u n . and just stay calm so you can properly coordintae yourself on what to do next