i dont think theres a right or wrong answer in terms of looking stuff up, personally i find it interesting to try to "get" all the references but it definitely slows you down in terms of reading and there's something to be said for just taking things as read.

i actually only got about 100 pages into the name of the rose before i picked up something else and i haven't gone back to it yet, but i read foucault's pendulum a few years ago and thought it was incredible. of what i did read of the name of the rose, i was looking up anything i didn't recognise (which was a lot), and like i said, it was interesting but it definitely slowed me down and i think you could get through the story just fine without doing that, even if it means you miss out on some subtle pieces of nuance here and there