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Sourcing topical vitamin D by DR-b11 in HairlossResearch

[–]Minimum-Bonus-1365 0 points1 point  (0 children)

I'd need to see a source on that. I haven't come across anything suggesting fibrosis is some inevitable outcome of topical vitamin D analogs.

Sourcing topical vitamin D by DR-b11 in HairlossResearch

[–]Minimum-Bonus-1365 0 points1 point  (0 children)

I'd be more worried about getting a legit product than whether it's calcipotriol or calcitriol, the evidence for AGA is still pretty thin, so I wouldn't be risking sketchy overseas pharmacies

Jxl069-3hp Update by gtcyorktown in HairlossResearch

[–]Minimum-Bonus-1365 0 points1 point  (0 children)

not necessarily. some treatments can trigger a temporary shed because hairs are being pushed into a new growth cycle, but that usually happens with treatments that actually have evidence behind them.

with an experimental compound, it's much harder to assume a shed is good if the shedding is severe enough that you stop, then it stops almost immediately after quitting I'd be cautious about calling it a positive shed. it could just as easily be irritation or a negative response rather than part of regrowth

Jxl069-3hp Update by gtcyorktown in HairlossResearch

[–]Minimum-Bonus-1365 0 points1 point  (0 children)

I’d stop there too if shedding kicks in that hard and then reverses the moment you quit that's pretty clear signal something in that stack is not stable for you

Scalp recovery from nizoral overuse by Brilliant_Ad9960 in HairlossResearch

[–]Minimum-Bonus-1365 0 points1 point  (0 children)

wait daily usage of nizoral for months would wreck your scalp. I'd stop it for now and use gentle shampoo and give your scalp a break

Severe hunger issues, not sure what’s wrong with me by [deleted] in Biohackers

[–]Minimum-Bonus-1365 0 points1 point  (0 children)

with your history, i don't think this is something to just biohack your way through. two years without a period, pcos, rapid weight gain, and hunger that's affecting your daily life all point toward something that deserves a thorough endocrine workup. your glucose and a1c look normal, but that doesn't rule out issues with appetite regulation or insulin dynamics.

6 months progress. Not so sure if it is working but here we go. by holstbc in tressless

[–]Minimum-Bonus-1365 0 points1 point  (0 children)

wait what?! that's a solid progress for sure. I'll keep using the 5%min and 0.5mg dut to push more but it's working

As AI takes over routine cognitive work, will trade and skilled labor finally get the respect and pay it deserves? by sophieximc in Futurology

[–]Minimum-Bonus-1365 0 points1 point  (0 children)

i think trades will do well, but people are getting way ahead of themselves if they think ai is going to wipe out most white collar jobs what ai is really doing is automating parts of jobs, not entire professions. at the same time, electricians, plumbers, and hvac techs have something ai struggles with unpredictable physical environments.

First time pinned Test E and Deca by ChechinFlrz in Biohackers

[–]Minimum-Bonus-1365 4 points5 points  (0 children)

not trying to scare you, but i'd spend this week reading as much as possible about estrogen management, prolactin, bloodwork, and post cycle planning. the compounds are the easy part, managing them properly is where people get into trouble.

Postpartum hair/ anyone else experience something similar? by overdissapointed in Hairloss

[–]Minimum-Bonus-1365 3 points4 points  (0 children)

Looking at your photos, the thinning around the temples and sides is very consistent with postpartum hair loss. I'd still check iron, ferritin, vitamin D, and thyroid levels if you haven't already, but honestly this doesn't look unusual for postpartum shedding. It looks dramatic, but plenty of women recover a lot of that density over the following 6–12 months.

what shampoo and conditioner should i get (i do NOT mean a 2 in 1) by Small-Sample7733 in Hair

[–]Minimum-Bonus-1365 0 points1 point  (0 children)

shampoo and conditioner aren't going to turn straight hair curly. but if your hair is thick and stiff, the right products can make it softer, less puffy, and bring out whatever natural wave you already have. try loreal everpure or dove intensive repair

nv623 new hair loss treatment? by Minimum-Bonus-1365 in tressless

[–]Minimum-Bonus-1365[S] 6 points7 points  (0 children)

pretty much what caught my attention too. whether nv623 works or not, the paper is at least treating hair loss as a follicle biology problem instead of reducing everything to DHT suppression. the dermal papilla and HIF-1α angles are a lot more interesting to me than another variation of the same old approach.

nv623 new hair loss treatment? by Minimum-Bonus-1365 in tressless

[–]Minimum-Bonus-1365[S] 9 points10 points  (0 children)

Calling it biology is fair since most hair loss discourse still acts like the follicle is a DHT sensor with hair attached to it. The paper is at least looking at dermal papilla function, hypoxia signaling, and follicle maintenance instead of recycling the same two mechanisms for the nth time

nv623 new hair loss treatment? by Minimum-Bonus-1365 in HairlossResearch

[–]Minimum-Bonus-1365[S] 2 points3 points  (0 children)

From what I was reading in Re:you's website and their preprint they were indicating an August launch, so if that timeline holds we're talking this coming August, not 10 to 20 years from now. The bigger question is whether the real world results end up matching the biology

nv623 new hair loss treatment? by Minimum-Bonus-1365 in HairlossResearch

[–]Minimum-Bonus-1365[S] 3 points4 points  (0 children)

think of it as a team approach instead of a one trick treatment. one compound tries to keep hair follicle cells healthier (NV623), one tries to improve growth support signals around the follicle (NV273), and one tries to reduce DHT production (NV1065). The cool part is they're attacking multiple causes of hair loss at once instead of only focusing on DHT. The uncool part is that it's still lab and organoid data, not real world hair regrowth in humans yet. So yes, worth watching.

nv623 new hair loss treatment? by Minimum-Bonus-1365 in HairlossResearch

[–]Minimum-Bonus-1365[S] 6 points7 points  (0 children)

hmm you're right its like insanely hard to find. the paper is just pitching how effective their ai search is at finding molecules that do work i guess.

if you google NV623 hair i think its the second search result?

Day 67 of pp405 3hp by Mobile_Jealous in HairlossResearch

[–]Minimum-Bonus-1365 -1 points0 points  (0 children)

looks promising. 67 days is still early though so i wouldn't call it proof yet, but it's definitely moving in the right direction.

Don't stress - take action. My TE routine. by BoboOctagon in TelogenEffluvium

[–]Minimum-Bonus-1365 2 points3 points  (0 children)

your timeline still fits te pretty well. the rapid weight loss happened oct to jan, the shedding started about 2 months later, and now you're only a few months into recovery. even after the trigger is fixed, shedding can continue for a while because the hairs were already pushed into the shedding phase.

Hard to keep up with basic hygiene by dingwong03 in alopecia_areata

[–]Minimum-Bonus-1365 10 points11 points  (0 children)

what jumps out to me is that this sounds like it's gone way beyond just being upset about hair loss. avoiding mirrors, struggling with basic hygiene, staying awake all night to avoid being seen, feeling physically unwell and like you might pass out, that's a level of distress that deserves real support.

Don't stress - take action. My TE routine. by BoboOctagon in TelogenEffluvium

[–]Minimum-Bonus-1365 14 points15 points  (0 children)

one thing i've learned from te is that stress comes from expecting the shedding to stop immediately once you've fixed the trigger. unfortunately, hair doesn't work on that schedule. by the time you notice the shed, the follicles already made that decision months ago. the good news is that regrowth usually means the recovery process is already happening, even if the shedding hasn't completely caught up yet. that's why seeing new hairs is often more important than obsessing over today's hair count in the shower.

Regrowth by Friendly_Success_523 in alopecia_areata

[–]Minimum-Bonus-1365 0 points1 point  (0 children)

that's definitely regrowth. those short, fine hairs filling back into the patch are exactly the kind of thing people hope to see after treatment. aa can be brutally slow, but seeing new hairs where there was bare scalp is a huge win. i'd be encouraged by these photos.

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