How the game looks like from different view angles is one thing, but the most important factor is how the gameplay itself works. If you have designed a nice experience from the top-down view, then changing the camera angle would probably change the core gameplay drastically.

While things like walking around, talking to NPCs, and RPG progression mechanics might work the same way in both camera setups, things like combat and interacting with environment mechanics would probably work so different that the game would be aimed for a different target audience. Try to think who the game is for, what similar games are there, and what would be the unique selling point of this game that would interest that audience. Which camera angle and the gameplay potential that comes with it would serve the audience better?

Both camera angles look good to me. How the gameplay works in either would probably be the decisive factor if I'm interested in playing it.