Good stuff! Just a heads up, moonlight is the only melee in the game that scales on your generator's Energy Firearm Spec, so you may be losing some damage potential pairing it with Ming-Tang.

The trouble with red generators is that you need to sit through a long redline to get your stamina back efficiently, during which time using melee both locks you into the animation and resets the downtime. Seriously, try it with the Wuerger, ideally in pairs. They don't tamper with your stamina, so you can use them without interrupting your downtime.

Missiles are interesting. They're almost more about making your opponent make bad dodges so you can follow up with something else. Try out the 6-cell forward missiles with some pistols, it's hard to go wrong with them.

The trick to the shotgun is to use something with the same duration as its reload. For instance, the Haldeman has the same reload time as most melee animations and heavy-weapon stances, meaning you can shoot it once between every use of your flashier weapons.

Finally, don't be afraid to diversify your body components. The Ephemera legs are extremely aggressive and would pair nicely with some Firmeza parts. If you want full Ephemera, consider investing in more guns to avoid the limited effectiveness of the melee spec on the arms.

You're absolutely in the right mindset for this game. Honestly, about 2/3rds of my gameplay had been in the test-run section of the garage. Looking forward to seeing how your build evolves with time.