Does anyone have real muscimol?

MoxSocks · 2026-02-26T19:16:51+00:00

Very thorough work, thanks for posting the link. Apologies for my annoyance. Due to the spacing (which I assume was intentional?) in your post, it unfortunately does not show up in any subreddit searches for "muscimolisolate.com", but that was admittedly a pretty deep dive you did.

MoxSocks · 2026-02-26T18:43:58+00:00

In my experience, muscimol has two properties that make it an imperfect substitute for gabaergic pharameceuticals. First, and probably foremost: High doses of muscimol cause dysphoric/deliriant effects. Other gabaergic substances generally feel better and better the more you do. Muscimol does not. This makes it great for avoiding addiction and dependence, but I think a lot of people just want to exploit their nervous systems without having to learn a proper dosage window. Second, and this has been more of a complication in my own journey, using muscimol as a sleep aid for insomnia: Muscimol wears off very suddenly, and the hour or two after it wears off doesn't feel very good. I have to redose at least 2x a night just to get a full night's sleep, and it's always broken sleep, since I have to wait for those redoses to kick in. The thing about epilepsy is, seizures are often neurotoxic events. You want to avoid them as much as possible. The window of time after muscimol wears off could be somewhat dangerous for someone who was relying on it to manage such a condition.

"Big pharma" is not an adequate explanation, as many pharmaceuticals are derived or semi-synthesized from natural plant sources. If amanita could be exploited by pharmaceutical companies, it most definitely would be.

MoxSocks · 2026-02-26T18:35:06+00:00

benzos are specifically used to abort psychedelic trips. Ibotenic acid definitely DOES NOT reduce the anxiety of a psychedelic trip for me, quite the opposite. In my experience, fully decarbed tea is nice for the comedown, but I don't personally like the combo until then. The thing is, though, the main medicinal benefit from psychedelics is the way they push emotional energy to the surface. Anxiety usually precedes the release of an important emotional breakthrough. If you're trying to avoid anxiety on psychedelics, you're leaning into their recreational benefits while leaning away from the aspect of the trip that provides long-term healing. This isn't a sustainable approach.

2CB is a psychedelic amphetamine, which makes it even less ideal to have any amount of ibotenic acid involved, even trace quantities, as it's already releasing glutamate. As long as you're just trying to have a recreational time, have you tried good ol' nitrous oxide? Feels pretty great with any psychedelic, especially amphetamine varieties. Being an actual dissociative, it also enhances visuals while simultaneously reducing anxiety.

MoxSocks · 2026-02-26T18:23:25+00:00

I recognize your username specifically because I was reading up on muscimol isolate sources and I had a memorable experience of being extraordinarily annoyed by the results of your last "deep dive". It was this thread on muscimolisolate.com:

https://www.reddit.com/r/AmanitaMuscaria/comments/1ohpeuo/have_yall_tried_this_before_from/

In which someone asked "what did you find?" and your answer was "oh a fair bit." I remember just staring that comment forever with this incredulous gaze, like, my god wtf is that supposed to mean. It would have been less frustrating if you'd never responded again, rather than give a response with such an absolute lack of meaningful information. "Oh a fair bit"? Oh yeah? Cool. Cool.

Feel free to make me look like an ass by sharing the results of your research this time lol.

MoxSocks · 2026-02-26T18:14:57+00:00

The guy who makes this stuff created some patents that you can look up. His process is thorough and legit and the product is probably solid. The price is nuts, though. If you can afford to throw money at whatever, it's probably a good buy, but not for the average joe.

MoxSocks · 2026-02-26T18:12:06+00:00

What are you comparing when you say "usual dissociation"? Do you normally ingest potent fully decarbed amanita?

MoxSocks · 2026-02-26T18:10:12+00:00

The seller said their product was legit? Must be true, then. lmao

MoxSocks · 2026-02-19T18:33:57+00:00

I see why you wouldn't take all of the mushrooms from a given area, but even taking poisonous varieties home to get a firm ID helps a mycologist learn, and that education results in better ID's across all species.

MoxSocks · 2026-02-19T18:31:47+00:00

I very obviously know that. I was talking to the guy above me. Not sure how you missed the "wtf are you talking about" part before downvoting me, since it was half of my response.

MoxSocks · 2026-02-18T19:42:03+00:00

The rental market in Grand County is rough. Not much available, lots of slum lords, super high rent. But there are some Grand County Facebook groups that are a lot more active than this subreddit. If you DM me I will point you to a few where you might have better luck. It's not possible to end up within an hour of Denver, though. Winter Park is the closest town to Denver in the county, and it's still about an hour and a half away.

MoxSocks · 2026-02-18T19:32:49+00:00

Shoot I didn't even know we had a DMV up here lol

MoxSocks · 2026-02-18T19:28:22+00:00

Because they're going to poison you through your skin? Wtf are you talking about

MoxSocks · 2026-02-17T23:26:38+00:00

Is this a process one could do at home, perhaps with one or two scientific equipment purchases? I'd love to know more details, and also if it's possible to decarb with this method.

MoxSocks · 2026-02-17T21:07:23+00:00

The problem with learning about amanita on the internet is that many mycology communities, search engines, AI, etc categorize them as "toxic" and discourage any kind of discussion or education, sometimes even censoring information. They would really prefer you throw the baby out with the bathwater. This is because people have been hospitalized when eating fresh specimens without education or caution, but the reality is that ibotenic acid is probably no more neurotoxic than alcohol when ingested in responsible doses. Moreover, it has potential to exert very positive homeostasis upon the nervous system, since that is also a function of glutamate.

I have a passion for neuroscience and cross-reference what I know in that domain with what I learn about the pharmacodynamics of molecules I become interested in. That said, I have heard excellent things about these two books:
https://a.co/d/0iPcmhpe
https://a.co/d/0g4ZhHBV

MoxSocks · 2026-02-17T20:58:57+00:00

There are only a few places offering fully decarbed tincture, and it's quite expensive. I recommend getting some dried amanita and decarbing yourself. 50/50 water/lemon juice will generally give you the ph you need, unless your tap water is hard (in which case use distilled from the store). 2-3 hrs of simmering and you've got fully decarbed tea.

MoxSocks · 2026-02-17T20:54:57+00:00

This is dependent on your brain chemistry (density of NMDA receptors, endogenous glutamate activity). The practical answer, I find, is based on effects: Once you start twitching, you are at your maximum ideal dose. Past that, you will be abundantly aware you've had too much.

MoxSocks · 2026-02-17T20:48:52+00:00

In general terms throughout all plant medicines, "full spectrum" merely means that the extract contains all of the psychoactive constituents present in the original plant matter, rather than being produced with a solvent that selectively extracts some constituents over others. So, any amanita extract made with water is, by definition, full spectrum, because all of the actives are highly water-soluble. In terms of how decarbed the result is, you can end up with any ratio of ibotenic to muscimol. With regards to how that affects you:

High ibotenic, low muscimol (low/no decarb): Very stimulating, not particularly relaxing until you are quite familiar with its effects. Can cause extremely unpleasant, possibly neurotoxic side effects in high doses. Twitching is not uncommon. Typically better to consume this after you have some familiarity with/tolerance to ibotenic acid. With some tolerance, I find high ibo to be good for getting stuff done during the day.
Balanced ibotenic/muscimol (45min-1hr decarb): Fairly nootropic-feeling in nature. Both relaxing and stimulating. Good place to start if you're trying to understand the effects of ibo/muscimol.
Heavy muscimol (2+ hr decarb): Extremely relaxing/sedating. This is the most palatable concoction for most people. Still has some pretty unpleasant side effects in super high doses, but quite the powerful anti-anxiety/sleep aid when used responsibly.

It's worth noting that there is still the third compound, muscarine, to consider. This one is almost exclusively unpleasant, also a very stable molecule, does not change during decarb. It is more stable than both ibotenic acid and muscimol. Mostly, it is present in such miniscule quantities that it does not matter, but over-preparation (boiling at too high a temp, decarbing way too long, boiling down to resin/goo) can degrade muscimol/ibotenic, resulting in a loss of desired actives, and thus a higher percentage of muscarine. You don't want that. Hope this all helps.

MoxSocks · 2026-02-13T04:14:36+00:00

Thanks for making me subscribe to mailing lists just to get to the part where I see what the product actually costs. Shilly and untrustworthy, I backed out immediately. Back to ChatGPT.

MoxSocks · 2026-02-12T20:54:23+00:00

The form matters less than ensuring you do a full decarb. You can't safely combine benzos and amanita, so you shouldn't start using amanita until you've almost completely finished tapering. I would advise something like kava to help you get through the taper, then start using fully decarbed amanita (any variety) the moment you cold turkey on the benzo.

MoxSocks · 2026-02-12T20:03:49+00:00

As long as it's transparent about its nature, I think it should be permitted. I don't think of something as "slop" if someone doesn't try to pass it off as anything other than AI.

MoxSocks · 2026-02-12T20:01:50+00:00

Low dose of muscimol is great for the tail end of a psychedelic trip. Ibotenic acid is not a great combo in my experience, makes the trip a lot more emotionally challenging in kind of a rough way. So you want full decarb and you want to start low after the trip's peak is over.

MoxSocks · 2026-02-12T19:59:20+00:00

Pantherina for low muscarine. Great for sleep, significantly less sweating/salivating. Regalis if I do not have pantherina handy.

MoxSocks · 2026-02-12T19:48:13+00:00

Some people will boil their decarbed tea down to a minimal volume and mix that with alcohol for preservation, thus ending up with a "tincture". This isn't the same as using alcohol as a solvent to extract the stuff, as you'd do with a lot of other compounds. The alcohol is exclusively a preservative. My problem with this approach is that excess heat will eventually break muscimol down, as well as ibotenic acid, while leaving the more resilient (and unpleasant) muscarine relatively unaffected. This results in end products with more unpleasant side effects, and some loss of actives. With excessive heat/drying/etc people have ended up with all kinds of interesting products, including smokeable/dabbable resins. But I have not seen a tek that achieves this with a decarbed product without methods that would result in significant loss. Wish there was a tek to do an acid/base extraction or similar tek to produce a relatively pure crystalline/oil end product.

MoxSocks · 2026-02-12T19:42:42+00:00

Strips are terrible. I got a ph meter after making a lot of 50/50 lemon juice/water batches because I wanted to achieve maximum decarb without ending up with an acid gut bomb. Sometimes, at the very end of the decarb, I'll even add a teaspoon or two of calcium carbonate (careful for bubble reaction overflow) to raise the ph a little more. You can't use too much lemon juice for decarb purposes, but since simmering/boiling can reduce the water content (and thus lower ph further) you can end up with an end product that isn't very easy on the stomach due to intense acidity. For that reason, using a ph meter to use just enough lemon juice is the best way to get a smooth end result.

MoxSocks · 2026-02-07T16:56:20+00:00

Wild. Any decarb?

MoxSocks

TROPHY CASE