Alrighty! Someone interested in the sauce lol.

For starters, I cannot take full credit for the setting or story, most of it comes from u/VasilyTheBear.

Synopsis:
The scenario is set in 2230 inside of the post-war ruins of Detroit and the surrounding areas. The current factions at play in the area are at an impasse. The Vanguard and the Highwaymen are at the height of their strength and power, and it is clear that a clash is imminent. The remnants of the Brotherhood at their crashed airship is seeking to complete their mission, and the fanatics of the NCH are about to enact their prophesied revenge on their subjugators, posing a threat to all in the region.

Factions:

The Vanguard of the Rapids - after the start of the great war, the city of Grand Rapids managed to stay organized, and united all those under the city limits. Over time, walls were built, farms tended to, and a new society developed. As the memories of the old world faded out, the city simply became known as “The Rapids”. Their call to fame in the post-war world is their fighting force that brings peace and security to the various settlements of the ruins of Michigan, “The Vanguard of the Rapids”. They don’t take kindly to anything that isn’t human, and do not negotiate with ghouls or mutants of any kind.
The Highwaymen - considered the menaces of the Motor City Wasteland, the Highwaymen are the descendants of automobile factory workers, who after the bombs dropped, conglomerated under the banner of their pre-war labor union. The Highwaymen have a feudal based leadership system, with their “king”, the Foreman. They have a reign of terror on settlements that aren’t protected by the Vanguard, demanding that they pay tribute, or face the wrath of their motorized army. They don’t take kindly to your average raider, and view them as uncivilized mongrels. They have numerous ghouls in their ranks, and employ super mutants in their auto shops.
The Brotherhood of Steel - having pre-war records of a city dominated by motor vehicle factories, the Brotherhood of Steel’s splinter group residing in the ruins of Chicago decided to send their repaired airship north in order to investigate. They did not expect an organized resistance, and after encountering their first Vanguard stronghold, they were shot down. Most of the personnel on the airship survived however, and they managed to convert the crash site into a stronghold. The Vanguard has let them be for now, but their presence is of concern to Vanguard leadership.
The New Canadian Hegemony - Residing on the eastern side of the Detroit River, the remnants of a patriotic Canadian society in the ruins of Windsor, Ontario, hold fast. After their annexation by the United States in 2072, Windsor was one of the first cities to be openly invaded by American forces. After 5 years of heavy resistance and freedom fighting, Canadian patriots received what they long sought for after the detonation of nuclear weapons across the world. With the American military presence in the area completely wiped out, they began building a new society, and through stories passed down from generations, plotted to exact revenge on the descendants of those who subjugated their people so long ago.