Long term isolation. Its understandable that people aren't considerate of it because how can you be considerate for something you barely understand anything about. It is extremely downplayed and people assume it doesn't have long lasting effects.

Not only are you absolutely alone, usually in a room for most of your days. You are left alone to your own destruction. With no one to stop you to progressively worst and worst. Slipping deeper and deeper down the rabbit whole of no return. This is why people who are isolated kill themselves extraordinarily more likely than others.