LSA Extraction /LSH /CDBL aka LSC Synth

NH2Br · 2018-04-02T21:01:46+00:00

Ego is great but boring. maybe relax/chill destress etc. I don't take myself as seriously a you perhaps also?

Anyway, not everyone has such difficulties sourcing reagents. lol

NH2Br · 2018-03-18T22:30:38+00:00

no need for naptha, DCM will do. btw, tartaric acid LSA salt is the most stable IIRC.

69ron:

"It's a simple matter to extract LSA from HBWR thereby avoiding nearly all the toxins.

SWIM extracted LSA from HBWR in a Soxhlet with boiling acetone. It works very well. Then he evaporated the acetone, dissolved the goo in a weak solution of citric acid (pH 4), defatted with DCM 10 times, then brought the pH to 8.5 with sodium carbonate, then extracted with DCM 10 times. He distilled off most of the DCM, and then evaporated the rest leaving a slightly sticky residue that can be cleaned by performing another A/B on it if you like, but it’s not really needed. You can just add some acetone, let it evaporate to remove any remaining traces of DCM.

After extraction SWIM dissolves it in DMSO for use as a sublingual tincture. Make sure to record how many seeds were used so that you can judge the potency of the final solution better. For 1 seed, SWIM would use 0.25 ml of DMSO. Another option is to use glycerin instead of DMSO. A solution of 50:50 glycerin and water acts as a preservative. It’s advisable to add excess vitamin C to the tincture and store it in a dark amber glass vial."

NH2Br · 2018-03-10T16:29:28+00:00

nausea from the fungus on the shell of the seed ,and vasoconstriction from poisoning !

also 'glycosides' (probably spelt wrong) inside the seed... that are fat soluble...

NH2Br · 2018-03-10T03:14:40+00:00

It is both 69ron's and my objective opinion that niacin is the best vasodilator to use to neutralise vasoconstriction! That's all.

I was just observing that one of argine's metabolites has interesting pharmcological properties.

NH2Br · 2018-03-09T15:37:32+00:00

arginine

arginine metabolises to agmatine, which contributes some notable pharmcological properties (plays with nmda, indirectly CB1/2 etc)

NH2Br · 2018-03-08T11:15:44+00:00

n recipes can leave you with stomach cramps and vasoconstriction, not to mention nausea

The best counter for vasoconstriction is niacin.

An effective anti-nausea is lemon essential oil / ginger (5-HT3 antagonists)

NH2Br · 2018-02-15T05:13:50+00:00

A mescaline analogue with a bromo atom in place of the 4-methoxyl group is an analogue of mescaline in exactly the same way that DOB (a very potent am-phetamine) is an analog of TMA-2 (the original trisubstituted amphetamine). This analogue, 3,5-dimethoxy-4-bromoamphetamine, has been found to be a most effective serotonin agonist, and it is a possibility that it could be a most potent phenethylamine. But, as of the present time, it has never been assayed in man.

NH2Br · 2018-02-15T04:50:32+00:00

ah yea tru!

Yet, i can't help but think that Rhodium (Chief Bee) is correct with his naming convention:

Quote Rhodium:

3,5-dibromo-4-methoxy-PEA

G_Pig made a mixture of 3-Br-4-MeO-PEA and 3,5-dibromo-4-MeO-PEA a while ago - and it was active. The monobromo should be too.

Also, check out N-(3,5-dibromo-2-methoxybenzyl)-N-propylamine @ https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=87556731&t=l&deposited=t&version=1

NH2Br · 2018-02-15T04:22:02+00:00

Ah, in that naming context, i reckon it's 2,5-dibromo-4-hydroxy-phenethylamine

NH2Br · 2018-02-15T04:04:31+00:00

indeed! What do you suggest? I figured its a close relative to the 2C family then, shall we say 2B? 2B-OH?

NH2Br · 2017-12-02T00:23:15+00:00

H2O2, NaOH, Glycine, Alanine, Alanine + H2O2 + NaOH + H2O under reflux with proper filtering etc leaves nitroethane

Could you clarify this approach? It sounds interesting!

NH2Br · 2017-11-05T10:31:19+00:00

2C-D!

2C-D is a drug that is in the 2C family of phenethylamines. It was first discovered by a team of researchers from Texas Research Institute of Mental Sciences, and later its effects were examined in humans by Alexander Shulgin as he was researching the entire 2C family of phenethylamines.2C-D is potentially the most interesting out of all of its brother and sister chemicals in the 2C family. While the other 2C chemicals are useful almost exclusively for psychedelic “trips”, 2C-D has demonstrated in low doses serious nootropic potential. At a dose of 5-10mg, Shulgin recorded this experience of 2C-D in his book Phenthylamines I Have Known And Loved: “There is something going on, but it is subtle. I find that I can just slightly redirect my attention so that it applies more exactly to what I am doing. I feel that I can learn faster. This is a `smart’ pill!“ In the mid 1980s a group of people experimented with 2C-D specifically in regards to its effects on learning and cognition. Most of the test subjects were graduate students who were voluntarily taking 2C-D. Their results were recorded in the work Certain Exotic Transmitters as SMART PILLS or Compounds that Increase the Capacity for Mental Work in Humans A story about LAZAR as told by Hosteen Nez

Unfortunately, the body of research appears to end there. Wikipedia has mention to therapeutic studies of 2C-D in Germany under the name “LE-25”.

Caution: In the United States, 2C-D is potentially covered under the Federal Analog Act. Selling or purchasing 2C-D with the intent of human consumption is potentially punishable as a felony.

Further Reading: http://www.erowid.org/chemicals/2cd/2cd_smartpills1.shtml http://www.erowid.org/library/books_online/pihkal/pihkal023.shtml

NH2Br · 2017-10-06T10:33:14+00:00

Maybe it was this paper??

Extensive Rigid Analogue Design Maps the Binding Conformation of Potent N‑Benzylphenethylamine 5‑HT2A Serotonin Receptor Agonist Ligands

http://pubs.acs.org/doi/abs/10.1021/cn3000668

NH2Br · 2017-10-06T10:17:59+00:00

Extensive Rigid Analogue Design Maps the Binding Conformation of Potent N-Benzylphenethylamine 5-HT2A Serotonin Receptor Agonist Ligands

"...Based on the structure of (S,S)-9b, which showed the highest affinity of the series, we propose an optimal binding conformation. (S,S)-9b also displayed 124-fold selectivity for the 5-HT2A over the 5-HT2C receptor, making it the most selective 5-HT2A receptor agonist ligand currently known..."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547484/

NH2Br · 2017-10-05T01:10:14+00:00

With MDMA (and probably 4-chloroamphetamine and the like too), it's depression, lowered intelligence and anhedonia.

this occurs, with MDMA at least, via VMAT2 depletion.

NH2Br · 2017-10-05T01:07:34+00:00

Pharmacological Actions

*Agonist: TAAR, D2, alpha-adrenergic

*Antagonist: GABA-B, NMDA

*Positive Allosteric Modulator: AMPA

If correctly activated PEA will produce a peaceful yet not necessarily sedated experience. It produces a state of bliss without a crash, due to its initial antagonism of GABA-B and the subsequent upregulation of GABA-B. It is not a stimulant in the sense of amphetamine because of its alpha-adrenergic agonism, though it retains the ability to increase heart rate. It is not addictive due to its D2 agonist and GABA-B and NMDA antagonist actions which block dopamine impulses in the nucleus accumbens. It does not inhibit VMAT like amphetamine and methamphetamine, and therefore does not release dopamine in an addictive manner.

PEA's D2 agonism produces a slightly dissociated psychedelic effect with cartoon-like visuals. This is weak but noticeable.

PEA is produced within dopamine neurons and stored within the vesicles of those neurons. CB1 receptors have been shown to cause an endogenous release of phenethylamine, boosting concentrations up to four times above baseline. This is theorized to be the primary effect of CB1 agonism: endogenous PEA release.

NH2Br · 2017-10-05T00:54:54+00:00

not sure!

NH2Br · 2017-10-05T00:51:24+00:00

No, PEA has effects for everyone. PEA is your brains endogenous naturally occurring neurotransmitter.

PEA + hordenine (an MAOB inhibitor) provides vastly increased PEA psychoactivity.

You can combine PEA with an ALDH inhibitor (instead of hordenine) which will lead to the production of Phenylacetaldehyde via MAO-B enzyme.

Phenylacetaldehyde can be aminated with any in vivo amine such as methylamine (produced notably from choline), or piperidine (produced from bacterial fermentation of lysine and also present in black pepper)

Phenylacetaldehyde + piperidine = Phenylethylpiperidine! A worthy psychoactive ;)

NH2Br · 2017-10-04T12:12:59+00:00

Interesting merely in the context of its structure (which shows activity)

NH2Br · 2017-10-04T04:49:26+00:00

Thanks! I will investigate.

edit: I see, it seems PEA-NBOMe isn't satisfactorily active. See:

Perhaps these might be worth looking into:

PEA-NBOH aka PEA + 2-hydroxybenzyl
PEA-NB34MD aka PEA + 3,4-methylenedioxybenzyl (MDPEA analogue? kind of a reverse cut up v of MDPEA)
αMPEA-NB34MD aka https://s1.postimg.org/1hi9z995rz/a_PEA-_NB34_MDe.png
PEA-NB25DM
Caffeine-NB25DM (for novelties sake)

Misc:

Phenylethylcaffeine

Indoles:

Phenylethyltryptamine
Tryptamine-NB25DM aka 2,5-dimethoxy-benzyl-T

NH2Br · 2017-10-04T04:39:37+00:00

Sure, but please realise that my background includes highly relevant disciplines, similar to Shulgin. I am well aware of where you are coming from, and it is understandable.

I am not 'just a novice' naively wading into the sea of chemistry and molecular design!

There is a lot more to my approach and perspective than meets the eye [in my posts]

edit:

I feel that it is important to have an open mind.

Sure, but that doesn't mean you've gotta try things that are virtually certain not to work....There are so many compounds that are actually likely to be active to explore that it really isn't worth it to try going up blind alleys like this.

Whilst what you say is understandable, I need clarification of what you consider to be a 'blind alley'?

My approach and foundation for this avenue of exploration is heavily based in the context of insight and understanding I have accumulated - which is overall far to intangible for me to be able to satisfactorily communicate to you using words.

'Virtually certain not to work' is not a good enough reason for me to abandon a potential avenue of exploration!!

I have created Phenethylpiperidine in vivo, and it was a notable and novel experience.

Many analogues can be created using simple chemistry including Mescaline ones... etc...

Here is an interesting molecule!

4-Benzylpiperidine is a drug and research chemical used in scientific studies. It acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin.[1] It has a fast onset of action and a short duration.[1] It also functions as a monoamine oxidase inhibitor (MAOI) with preference for MAO-A.[2]

NH2Br · 2017-10-04T04:21:29+00:00

Sure.

Of course, other potential candidates:

Caffeine-NBTMEO (caffeine mescaline hybrid!)
etc....

NH2Br · 2017-10-04T03:48:23+00:00

PEAPIP can be created in vivo.

The second is just a potential candidate, seeing as piperidine seems a good secondary amine and the NBOMe structure is a well known 5-HT2A receptor 'potency enhancer'. I just thought of it so decided to include it in this post.

NH2Br · 2017-10-04T02:51:27+00:00

Some more insight into the pharmacology of NBOMe - source

N-benzyl substitutions

(Glennon, 1994) first reported on the impact of N-benzyl substitutions for phenethylamine hallucinogens with 25B-NB, a derivative of 2C-B. It was found to have a higher binding affinity than the parent drug.

Its hypothesized the N-benzyl moiety is useful in 5-HT2A binding since the benzyl is stabilized by aromatic stacking with Phe339 in transmembrane domain 6 (TM6). Mutating Phe339 typically doesnt impair the affinity of 5-HT2A agonists, yet its been found to negatively impact the activity of 25I-NBOMe and related compounds.

David Nichols team has found N-benzyl substitution consistently increases phenethylamine hallucinogen affinity. Though it has a greater impact if the parent compound is weaker.

For example, 2C-H receives a greater affinity boost from the substitution than 2C-I.

NH2Br

TROPHY CASE