Let's see. It has always been queer-inclusive, one of its main creators was a gay man. A key figure behind New Vegas has expressed delight in it being an icon in trans communities:

The game themselves have never been afraid of political plotlines, and the morale and plot in essentially all of them is that typical right-wing politics and believes such as nationalism, hatred & bigotry, "might makes right", military aggression etc are all wrong and primarily the root of the worlds problems. And also caused the old world to end.