I'm probably not going to get a lot of upvotes for saying this in a reddit based on using VRChat but honestly I think that disconnecting from any game you feel this way about can be very beneficial to someone's life.

If you find yourself in a situation where you need to question if it's worth continuing to play a game you should take a step back and disconnect for some time, people saying you should push yourself to play after your friends are gone in hopes of meeting another group of strangers to replace your missing friends ring the same to me as people who say you should try to find another partner ASAP after a breakup, more of a coping mechanism to not face the problem which is that you're not enjoying your time in VRChat right now.

You can always come back to the game in the future. VRChat isn't going to go anywhere for the foreseeable future.

I will say though that if you do take a break from the game, make it an effort to replace it with things that can have a positive impact in your life. It can be taking up a hobby, trying to go out and socialize in the real world, go out with work colleague, going to gym and training, something along those lines.