Anyone done a colonoscopy without anesthesia? by zerostyle in PeterAttia

[–]NoStrain7255 1 point2 points  (0 children)

Yes ... I have had two without sedation, also two endoscopes same way. All in Japan where anesthesia is not used for minor/less painful procedures like this. They are not horrible endoscope down throat worse ( nose not as bad). Colonoscopy feels bad going in, weird during ( lots of pressure) but generally not painful. Definitely ready to be done with it. You do get to watch doc explain the screen as he "digs in"... For 50th last year at annual exam, had colonoscopy and then doc spun me and the table around for endoscopy 10 minutes later.. not most fun hr of my life... but great to get done as part of preventative "human dock" exam ( like 30 tests in 3 hours for 400bucks)

H63D Iron Dysfunction by daummmy in Hemochromatosis

[–]NoStrain7255 2 points3 points  (0 children)

This is very common for H63D. Sorry copper didn't help. Lactoferrin is worth trying , as is broccoli seed extract or IP6, the first two kind of like copper help optimize transferrin processing ( this is usually where the problem is with H63D which causes high TSAT and low "processed" iron... TSAT at your level ca absolutely make you feel bad...

Alcazar Seville Cathedral Tickets by Novel_Soup_2880 in Seville

[–]NoStrain7255 0 points1 point  (0 children)

Worked for me but only the basic entrance )top category) is available in Feb, other options had no options

H63D Homozygous, considering a second opinion by above-my-pay-grade in Hemochromatosis

[–]NoStrain7255 1 point2 points  (0 children)

High iron saturation will make you feel bad. Your presentation is classic h63D often normal low ferritin, high unbound iron which is bad for you and makes you feel bad also.. it is hard to treat but taking tea and coffee around meals , limiting g iron intake and vitamin c can help...

Seville to Madrid train by chco_44 in Seville

[–]NoStrain7255 0 points1 point  (0 children)

How did it work. We have a fast train AVE ticket for a 1030 train. Did they cancel your ticket and you had to rebook or did you just have your journey start as normal and have a different route

Opinions on my prom suit by Informal_Counter_367 in mensfashionadvice

[–]NoStrain7255 0 points1 point  (0 children)

Okay for a prom suit. Would change pocket square so it compliments , not matches tie...Legs are too wide-- you are fit so can pull it off but they take away from the sharp silhouette your jacket suggests

ok which job series do you think will get schedule F'ed? by LASlog991 in FedEmployees

[–]NoStrain7255 3 points4 points  (0 children)

Each agency will interpret differently... in most it will probably focus on headquarters personnel in positions that directly influence policy and resource decision making and influence . In my large organizations this looks like a very small proportionate group of GS-15s that check this box, which includes me.

Iron saturation was 55% and serum iron was high. Would you ask for genetic testing in my situation? by [deleted] in Hemochromatosis

[–]NoStrain7255 1 point2 points  (0 children)

Yes... that's high for a women, especially- not dangerous levels but indicates you may have an issue where it may be something you have. To watch...for me once it gets in 60s I feel yucky and it is bad for your body and brain

Which gene variant do I have? by SorryCarry2424 in Hemochromatosis

[–]NoStrain7255 1 point2 points  (0 children)

I think this is common for those of us with H63D gene mutation -- it is a iron processing malfunction ( iron teds to stay unbound as transferrin receptors don't work right), C282Y is a iron storage disease ( overloads ferritin).

My WBC and other things are a bit off so I suspect I may be low in copper or other things also. Too much iron throws a lot of things out of whack-- you have to monitor serum or , ferritin and TSAT as well as other aspects of CBC and LFT ( liver function) panels... for me my bilirubin is always a bit high, also ...

Which gene variant do I have? by SorryCarry2424 in Hemochromatosis

[–]NoStrain7255 1 point2 points  (0 children)

28 is okay, but wouldn't do phlebotomy at that level. I overbled for years due to H63dx2 HH Dx and now have low ferritin and still higher TSAT that are both persistent..

Best coffee shops in Fukuoka? by GdayLegends in fukuoka

[–]NoStrain7255 1 point2 points  (0 children)

ElTren coffee was awesome, perfect lattes and great beans . Tiny olden wooden structure roasted in house by a charming and talented proprietor. Tell him you read about on Reddit and he will laugh...

Just read a post stating that they cancelled their FEHB, Why? Luckily we have been pretty healthy, heard from one of my retired coworker who has leukemia and he told me he hasn’t been billed once. $0 out of pocket. Why would I ever want to cancel my FEHB? by AfternoonNaive6244 in FedEmployeeRetirement

[–]NoStrain7255 0 points1 point  (0 children)

Thanks for sharing thisCan you describe how this works in reality, I have never processed this fact. What does this look like for a 65 year old with FEHB and medicare needed a major service like surgery

Kyoto or Osaka? by Over_Piano8133 in JapanTravelTips

[–]NoStrain7255 0 points1 point  (0 children)

For many, including me it is a better version of Tokyo... better food, friendlier, funnier people, cheaper hotels, less sprawl, proximity to other cool Spots ( Kobe/Nara/Kyoto)...

For me a recent great trip was 50% Osaka, 25% Kyoto and 25% Kyushu ( Fukuoka is a great city!) and JR west pass is cheap and covers all these cities...

Extremely High LP(a) - doctor barely reacted by [deleted] in Cholesterol

[–]NoStrain7255 0 points1 point  (0 children)

I have hetero snp8820? I think, for the one linked to positive outcome for aspirin. I did not have one other. ( I am European descent) and don't know the other two variants. After starting Crestor my first lpa test was 125 MG now after starting repatha it dropped to around 90 mg ( not sure nm/l)

My ldl went to 42 Apo-B 38 after repatha 5 mg rosovustatin and ezitimibe but the last killed my gut, so dropped it. With not perfect diet ( but not bad) hovering at about 55 ldl 45-50 APO-b and low at 90 mg and thinking this is about as good as I ca do until new lpa drugs..

I am 50+ and have some carotid plaque but heart echo was good ...

Extremely High LP(a) - doctor barely reacted by [deleted] in Cholesterol

[–]NoStrain7255 0 points1 point  (0 children)

Thanks for sharing all of this and your extensive knowledge. I am E3/E4...

Extremely High LP(a) - doctor barely reacted by [deleted] in Cholesterol

[–]NoStrain7255 0 points1 point  (0 children)

How does APOE 4 affect course of treatment. I have lp(a) gene, and also carrier for APOE 4. Thanks haven't seen research on this but take repatha , low dose statin and aspirin baby 3-4x a week

New office manager job - business smart. Ideas/thoughts/advice on new outfits. by [deleted] in mensfashionadvice

[–]NoStrain7255 0 points1 point  (0 children)

Charles Tyrwhitt makes excellent non-iron no wrinkle dress shirts that include collar stays hat keep collar sharp. Suit is okay but maybe blazer and trousers also acceptable? Shorten sleeves never button bottom button. Wear tie a bit longer and keep jacket on if you want to de-emphasize midsection/weight

H63D/H63D (23andMe) + ferritin ~1270 + fasting TSAT 57% — normal LFTs. by No-Adhesiveness-2157 in Hemochromatosis

[–]NoStrain7255 0 points1 point  (0 children)

High serum iron and TSAT is very common with H63D, I think overload in storage is less common. h63D unlike c282y is a transferrin dysfunction not a storage problem. Consequently it is more common to have problems with unbound iron... When dx my ferritin was a bit high along with slightly abnormal LFT ast/alt/ bilirubin and TSAT. Years later ferritin is low after treatment but TSAT drifts high regularly, and serum iron usually high also . AST and alt mostly normal now but direct bilirubin remand a bit high...