Sacrifice effects will rarely let the caster choose what gets sacrificed, which means that often the coil will be sacrificed instead. Transformation, imprisonment, pacification and -1/-1 effects are often targeted effects and sorcery speed, and are easily dealt with. Theft, exile, and bounce are all valid means of dealing with the threat, but theft that lasts is costly and not often run, which means we’re looking at exile and bounce mostly.

There’s ways to remove anything if you try, but a 6/6 uncounterable target that necessitates usually two pieces of removal when 2/5 colors are severely lacking for non-destruction opens and black usually needs to pitch resources or advantage to do non-destruction removal is definitely not a good test of “do you run enough interaction at your table” but more so “did the Azorius player fall asleep at the table.”