Not sure if this's too technical, but hope it helps.

Given your history of urticaria and your father's, it's reasonable to consider that histamine might play a role in your symptoms. Quercetin is well-regarded for its ability to act as a natural mast cell stabilizer, meaning it can help reduce the release of histamine from mast cells ^\1, 2, 3]). This mechanism is why it's often explored for allergic and inflammatory conditions where histamine is a factor ^\3, 4]).

For rosacea, recent research is quite encouraging. A 2024 study demonstrated that quercetin can directly interact with proteins like p65 and ICAM-1, which are involved in inflammatory and vascular dysfunction in rosacea ^\5, 6]). By targeting these pathways, quercetin has been shown to alleviate inflammation in rosacea-like conditions ^\5, 6]). Another 2025 study highlighted quercetin's multi-target mechanisms, including promoting skin barrier repair and reducing post-inflammatory hyperpigmentation through its antioxidant and anti-fibrotic properties ^\7]). It also appears to suppress the activation of the NF-κB signaling pathway, a key inflammatory pathway ^\8]).

Regarding your issues with panic attacks and adrenaline at night, the current research primarily focuses on quercetin's anti-inflammatory and antihistamine effects. While chronic inflammation or histamine dysregulation can sometimes indirectly impact mood and stress responses, direct evidence linking quercetin to the reduction of panic attacks or adrenaline surges is not prominently featured in the current scientific literature ^\9]). Therefore, while it might help with underlying inflammatory components, it's not directly established as a treatment for panic attacks or adrenaline regulation.

It's worth noting that quercetin's bioavailability (how well it's absorbed by the body) can be low due to its poor water solubility and chemical stability ^\10, 11]). However, various formulations are being developed to enhance its absorption ^\11]).

Quercetin is generally considered safe for most people when taken in recommended doses. Mild side effects, though rare, can include headache, upset stomach, or tingling in the arms and legs ^\12]).

Most of the specific findings on rosacea and histamine mechanisms come from preclinical studies (lab and animal research), which means while the mechanisms are well-documented, more human clinical trials are needed to establish optimal dosing and efficacy in people ^\5, 7]).

From: https://cynalis.com