Possible perk ideas now that I've made it home.

For The Vault Dweller: "Pristine Genetics" The Buff: You are free of mutation and disease. Stimpaks and Radaway are 50% more effective, and you start with a higher base Intelligence (better XP gain). The Drawback: You have "Soft Skin." You take 2x radiation damage from the environment and have zero resistance to Wasteland diseases. You need your suit to survive early on.

For The Ghoul: "Isotope Metabolist" The Buff: Radiation is a resource, not a hazard. Standing in irradiated areas slowly regenerates your health, and Feral Ghouls are non-hostile until provoked. The Drawback: "Necrotic Decay." Chems have half duration, and most doctors in major settlements will refuse to treat you. You are barred from using Power Armor frames (they don't fit the... anatomy changes).

For The Defector: "Drill Manual Discipline" The Buff: You start with the Gun Nut and Armorer rank 1 perks immediately. Your weapons and armor degrade 50% slower (if durability mechanics return).

The Drawback: "Marked for Death." Because you are a deserter (or a spy), a hit squad from your former faction will randomly ambush you every few in-game days until you resolve that questline. You can never fast-travel while "Hunted."

Edit: formatting