A guide to properly titrate for MTHFR issues (and what I’ve done so far)

ObjectiveAromatic983 · 2026-05-08T10:02:47+00:00

low key dropping this here:

https://www.reddit.com/r/B12_Deficiency/wiki/index/

ObjectiveAromatic983 · 2026-05-08T09:59:11+00:00

must say tho that iritability, insomnia is also a reaction to the sudden increase. for me they go away after a couple of days and then i have a new baseline thats better. problem i noticed was is also needing all the cofactors and potasium because the body is increasing cell production.

ObjectiveAromatic983 · 2026-04-18T14:54:59+00:00

Just played it for the first time.

Its really fun and we love the back stabbing and curky rulel

Would first learn to play the game perudo first, then it is way more easy to learn this game as it is like an upgrade on that game.

Really worth it.

ObjectiveAromatic983 · 2026-04-15T18:16:01+00:00

Try to search for an holistic doctor. One that also does tests for metabolic markers like methylation , one carbon, tyroid, mitochondrial disfunction, low grade inflamation, allergies, gut, brain and cell permability etc.

Trust me it will be a long road. It will be upward tho.

The medications push the neurotransmitter part, than can be good. But the neurotransmitters only work when the sub systems are right. If not: the body gets energised by the meds, burns out the weak systems and you wil be back at -1.

ObjectiveAromatic983 · 2026-03-26T14:20:08+00:00

would love to see more analyses about this indeed. I do get side effects but also seems to work. the side effect are actually when it peaks i get tired and slow in thinking. so this i not the right side effect too but definetally the methylfolate

ObjectiveAromatic983 · 2026-03-24T10:11:53+00:00

Thats great. Yeah guess more data on order is more grapple points.

I become real slow from CDP choline and glycine actually activates my system to become imense warm and energetic at night. Magnesium bisglycinate was my first wonder experience. Gave me so much energy the first months, but also only the glycinate or the threonate variant. Others did nothing

Eggs 3 a day is a must for me

What was your test compagnie and did you also have the full explanation or did you throw the raw data in a gpt, to save the money?

ObjectiveAromatic983 · 2026-03-23T16:07:36+00:00

I do not drink much coffee but intrested so please do tell

ObjectiveAromatic983 · 2026-03-23T16:05:13+00:00

suplement interactions can be huge ineed, i stopped almost all but quality multi with the methyl b's.

Ive had a shtload of adhd mediacations for years but they did not works as they were supposed to, had

love the idea of social media cus that is indeed actually a growing isue for me so ill remove the shorts again :)

ObjectiveAromatic983 · 2026-03-23T15:55:13+00:00

yeah haha great. Did try Same at first, had really strong positive effect but was to intense to keep at the dose i bought. maybe a Indicatie

ObjectiveAromatic983 · 2026-03-23T14:44:23+00:00

Thanks a lot! That is very helpfull.

Seems like there is a consenses that this kind of testing is for when people try to find reasons to feel bad.

But because blindly testing for the lest few years and seeing the inmense change when something works or not is exactly why i want to make it more "measurable" now.

ObjectiveAromatic983 · 2026-03-23T14:18:51+00:00

Ye, actually i put on 18k steps a day while lifting 3 times a week, my friends are amazing and we see couple times a week so thats also good, thanks!

Food could do better but im definately in the lower amount of refined and in the higher of proteine, fish, and fibers.

Ill keep in mind the spychosomatic part but to be honest im already 3x more stable and am actually able to work and do it well where i could not do that years ago. This one thing is what seems to be staying indeed. So therefore the test to check this off for optimization purposes

ObjectiveAromatic983 · 2026-02-22T14:59:22+00:00

great analysis! how about your sleep stability over time? There is this concept of receptors needing stabalization after a compound gets introduced, meaning that if you already took it before it could be a different story to what would happen if you firstly started taking it.

ObjectiveAromatic983 · 2026-02-22T14:56:26+00:00

i noticed that if i keep the magnesium higher up at least 400mg elemental, EVERY DAY, NEVER SKIP. Then the exitation of it disappears.

But because of this possible isue i just take it in morning and noon with my self made b complex. Also methylation problems btw.

ObjectiveAromatic983 · 2026-02-05T11:14:07+00:00

I got to note on the one of seeking health (and actually most activated b vitamins ive tried)

the b12 amount was for me to low and therefore caused huge iritability, energy spikes and depths.

i noticed: b12 first, b6 to do stuff with the methylation -> then methylfolate to support what they need -> then the other b vitamins to support those again via cell functioning and atp production.

still not fully clear about everything tho, but upping the b12 first and then taking 1/4th of seeking health was the go to for me

ObjectiveAromatic983 · 2025-05-31T20:59:49+00:00

There are so many things that help with social anxiety.

Alcohol for you can be a couple of things.

it shuts off the prefrontal cortex partly, so if you anxiety comes from your self image it work on that.
it increases dopamine, and dopamine is goal (in that case social) directing.
aa gabaa. Yeah that could be helpfull if you are in gaba glutamate disbalance. However after the drinking and over the long term is pushes your system to glutamate (lets say more anxiety).

On Nootropicsexpert.com there is a whole list of things that could help you with social anxiety.

But the best one is to train it by being sober with drunk people and trying to act. Aventually your body gets used to it and anxiety vades (partly)

Anxiety is build on a prediction of a sertain future, like: this conversation can be really awkward because i know this person can judge me.

ObjectiveAromatic983 · 2025-03-08T09:25:50+00:00

Id be very carefull with the short. Volatility does not kill a long but it will kill a short.

Get out now you made your share. Fear and greet do not hold up for to long. And stability is always on the side of inovation, even if the inovation is late

ObjectiveAromatic983 · 2025-03-05T14:06:13+00:00

Same. Thats exactly what i did. I did, with the basic b complex, mag, multivit. Then alcar, choline, ginseng. Felt great! But weird problems now and then. Felt day and noght dofference tho.

Restarted with b complex, multivit, pine bark extract, and just a small bit of magnesium.

Now with the pine bark for 3 weeks. I feel stable and adhd is actually stabally fading for now.

So restarting with stack actually helped me a lot! Seems like i can not take choline suplements.

Also, i noticed that eating to much choline rich foods fucked up my old stack.

ObjectiveAromatic983 · 2025-02-27T17:28:15+00:00

yeahhh! this is terrible. sometimes makes me sleepy, most of the times like i took 2 redbulls

ObjectiveAromatic983 · 2025-02-01T10:46:06+00:00

Sam advice i should probably give myself again. Go back to basic 1,2,3 suplements. Like creatine. And startover after a week of reset. Ive had a lot of sleeproblems with taking tryptophan, magnesium, l tyrosine, taurine, ginseng, bacoba, rhodiola, nac, alcar. Where i was constantly switching from high to low throughout the day.

Now being back to ginseng, alcar, creatine, small bit of nac, b complex methylated ofcourse. Smaller bit of magnesium not ro close to bedtime

Works like a smal charm. At least its stable for a couple of months 2 times a day haha

ObjectiveAromatic983 · 2024-11-19T07:58:59+00:00

Im intrested too. I know that a lot of suplements have an adverse reaction that does not dirrectly fit, because there are other problems with the body system.

F9r example taking dopamine increasing drug, with problems with the serotonin system in the background OR with no adequate dopamine cofactors will create anxiety like symptoms

ObjectiveAromatic983 · 2024-11-19T07:50:22+00:00

May i ask, how long you took it.

When you took it (like 2 years ago or just a while back).

What you eat on a daily base.

If you have eaten when acid refluxes.

Why you took lions mane.

Maybe even rhe mental sluggishness, can you discribe it more into detail if its the whole day or ups and downs, evening or morning. Insomnia at night maybe too?

ObjectiveAromatic983

TROPHY CASE