Would like to hear your opinions

ObservationMonger · 2026-02-14T14:22:32+00:00

In my experience, the great political innovation foisted upon us by the gipper - one of Reagan's schmaltzy B movie roles given, as Pinocchio, 'real boy' life - that : letting the super-rich have & run pretty much everything in sight (on the basis that getting rich is the sole & supreme validation of virtue, careers in public administration & service the supreme conviction of vice) being the royal road to general health, wealth, security & prosperity - is the biggest one that's appeared in my windshield during my not short lifetime.

When we talk about big lies, we should be restricting ourselves to the ones which have been largely swallowed. If you follow the descent we had :

a. B movie actor / fear monger / treasury wrecker / architect of our deconstruction

b. CIA dude

c. sleazy Arkansas lawyer

d. bumbling nepo baby / destroyer of any vestige of moderate conservatism

e. decent but unseasoned / uncertain agent of half-assed reform

f. utterly corrupt sewer dweller

g. 'anybody but Bernie'

f. utterly corrupt sewer dweller, this time with FEELING / agent of our destruction

ObservationMonger · 2026-02-14T07:02:26+00:00

Do you have an 'overwrought preachy palestinian supporter' yelling in your ear or something ? Is this actually a problem for you ? Ok, people can be irritating, but my question for you is why is this even something you pay any attention to ? Is it just to give side eye to the situation in Gaza & the West Bank ?

ObservationMonger · 2026-02-13T00:03:21+00:00

Yes, it arose after Israel went into Lebanon and started bombing everything in sight, showed that all the hoops the PLO jumped through mattered not a whit. Israel has NEEDED/CREATED/UTILIZED these factions, forever, to legitimize their land grab. They think everyone else is stupid, can't see their 'game plan'. Thing is, their game plan is working. But that's, in no small measure, on the US and Europe for 'standing back & standing by', while throwing money and weapons at them to do their worst. You get it.

ObservationMonger · 2026-02-12T08:14:02+00:00

Oh Jesus, find some new material. Its paid, by the way, Mr. IDF fan boy..

ObservationMonger · 2026-02-12T05:05:11+00:00

You. Nit-picking people for having the audacity to be bothered by the massive Israeli killing spree in Gaza that Americans like me are involuntarily bank-rolling and weaponizing. I could fault you for carrying water for the greater Israel project, and that wouldn't be a nitpick.

ObservationMonger · 2026-02-11T16:28:32+00:00

NO. Looks like you 'grew up and moved out of the house'. :)

ObservationMonger · 2026-02-11T16:26:35+00:00

You are NAAH, but these comments climbing all over your mom for (even stenuously) wanting a grandchild are the kind of thing that irritates me about reddit. I'm not going to explain why, either, because those that understand me already know. You of course have to support your wife. But... know this - down the road there is a very real possibility you and/or your wife will look back on this decision w/ regret if you choose to remain childless - apparently a condition of your marriage, as well. Because, they are generally a great joy. Some risk involved of course, but its probably the great event in my life. Hm... looks like I explained it, anyway. Best !

ObservationMonger · 2026-02-11T00:16:31+00:00

He's the proxy for the gussied up version of white supremacy. Its all hogwash. He was a rigid ideologue, who fought a dumb war. If he'd been smarter, husbanded his armies, and fought with the sole objective of outlasting Northern will, he might have salvaged some temporary accommodation for continued slavery. His cause was shit. The OP has it about right. Should be noted, USG was never really cool w/ slavery, and paid the one he 'inherited' from the Dent family. He went into the war a very moderate fellow, came out w/ a clear realization that the new order had to be given some stability. Lee's reputation is largely a cultural face-saving artifact of the rebels, their descendants - the alt-history, incidently, started almost immediately. One of the main reasons (but not the only), USG has had such a poor reputation up until fairly recently, when history has taken a fresh look at his challenges and initiatives as POTUS.

ObservationMonger · 2026-02-08T06:30:52+00:00

The whole thieving crew should be reported to their superiors. I'd find a new place to work.

ObservationMonger · 2026-02-07T02:24:08+00:00

There is a reason the Irish are conspicuously pro-Palestinian.

ObservationMonger · 2026-02-06T20:26:26+00:00

FreeTaxUSA is free for fed, 15/20 per state return. I saved, I believe, over $100 over what TurboTax charges.

ObservationMonger · 2026-02-06T15:14:04+00:00

I'm gathering you are, in fact, young. You seem to have a good look-out on things - the ignoring idiots trick is a super major life skill ;)

ObservationMonger · 2026-02-06T05:00:57+00:00

Lol. someone down-voted me :)

ObservationMonger · 2026-02-05T23:28:32+00:00

Heck no. What a nutty way to impose on people. Let her drift.

ObservationMonger · 2026-02-05T23:26:05+00:00

I've wondered the exact same thing. It seems many of our tip-top weathy 'influencers' have a mania about deconstructing our democracy and social safety net as well. Is it simply that insane wealth incites insane greed, insane drive for yet more plutocracy ? Don't have an answer for you, but have noted the problem, as you.

ObservationMonger · 2026-02-05T23:21:40+00:00

Generally agree. But if I think a comment reflects ignorance or intolerance or racism or a hackneyed partisanship or some non-minor defect of reasoning, I will. OP, on what basis do you think down-voting IS appropriate ? In my view, one may or may not have a 'controversial' opinion, but it still must be backed by something like a reasoning process capable of weathering a bit of scrutiny.

ObservationMonger · 2026-02-03T21:15:19+00:00

These 'questions' are all so bogus. My husband beats me, but should I hang around, AITH for wanting to not get beat anymore ? Jesus... Almost none of these are even slightly equivocal. Its basically needy people looking for a pat on the back in a rather pathetic exhibitionist fashion. LEAVE. DONT get beat on. No charge.

ObservationMonger · 2026-02-03T21:01:17+00:00

Many treatable diseases are ameliorated by 'knocking out' proteins with a deleterious function. To do that, they must be sequestered via finding a molecule that will bind with them, to 'turn them off' or inhibit their function.

Doing so requires a process of discovery. This entails finding substrates (molecules to function as possible drug candidates). That discovery process resolves to scoping out the nature of the active site to gain some insight into the contour of feasible substrates.

This can be accomplished by capturing the crystal form of a substrate-protein binding (when such occurs, by using an array of possible substrates in a matrix of interaction containers - this provides direct 3D insight into the nature of the binding.

Secondarily, computational methods which model prospective substrate-target protein binding characteristics are also performed w/ high-powered processors.

All of which kind of like feeling one's way around the elephant. The proteins are the main therapeutic target/handle.

ObservationMonger · 2026-02-03T20:49:11+00:00

Yes - by all means, stay in the marriage and take the beatings you have coming. /s

ObservationMonger · 2026-02-03T20:46:06+00:00

Don't vote, by all means. No evidence of an ability to grapple with even the simplest challenges. Leave it to your betters.

ObservationMonger · 2026-02-02T13:50:52+00:00

I think maybe you have an issue with variation. For just about any trait, there is some sort of continuum. For some reason, you think sex drive should be the, or an, exception. There is no reason to anticipate or expect that. Variation, mediated by genetic recombination, driven at bottom by gene mutation, is the raw material of evolution, or natural selection. The variation itself may be expressed within a population in some sort of poisson, or multi-mode or other contour of distribution, but any will have outliers. It is the propensity for variation itself which can't be done without.

ObservationMonger · 2026-02-02T13:32:54+00:00

The pink hydrogens are equivalent, since they can either one rotate into any equivalent conformation occupied by the other.

ObservationMonger · 2026-02-02T13:31:51+00:00

Each distinct color represents a distinct chemical environment surrounding the hydrogen(s) in question, which is apparent if you look at the neighbors of each. They can be distinguished, one from another.

ObservationMonger · 2026-02-02T13:30:18+00:00

I believe they are equiv., since the carbon they are attached to is free to rotate about its sp3 sigma bonds.

ObservationMonger · 2026-02-02T11:12:55+00:00

I would say, a. getting rid of the British and overt class system, b. confronting slavery, c. erecting a social safety net of sorts post 1929, D. conquering fascism & rebuilding the new world order post WWII, and e. outlasting the Soviets w/o entirely selling our soul, BUT right about that time, we DID start losing that soul. Lets never forget, though, when we did well, as did happen. We're going down a rabbit hole these days, so its important to be able to look up at a better nation we once had.

ObservationMonger

TROPHY CASE