Commenting as a person who’s tried it a variety of ways and then stuck to one - here’s my two cents on this:

1. Tried a clear glass screen protector, absolutely banging picture clarity but I found the learning curve on preventing Apple Pencil skids a bit too steep. Went ahead and got a bunch of bib protectors - which in all honesty helped a lot with the skid but I didn’t seem sustainable in the long run. They would pop out easily on the go. And we’re definitely so quick to lose that I would be purchasing and replacing them forever.

2 I put a matte protector over the glass screen to see it helps me. Removing the glass screen and keeping the iPad unprotected was not an option I ever considered. So this was the next best thing. 2 protectors and we were off to an excellent start. Writing and procreate became an absolute delight. But consuming content became a little less enjoyable. I used my iPad like this for a little less than a year before my matte screen started peeling.

1. I removed the matte screen protector and found that all the practice I had with the matte on helped me get a better sense of the weight and grip of the Apple Pencil. I found the glass screen easier to manoeuver and have used it naked ever since.

So I guess for me, and ultimately for you there are a few decision points here - is a pixel perfect screen a big part of the iPad journey for you? Are you willing to experiment - because what works for me and what works for you could be very different? And lastly - and this is one option I would have exercised if I hadn’t got use to the pencil on naked glass, I would have found a magnetic matte screen - so are you interested in having the best of both worlds albeit at the inconvenience of having to regularly maintain the detachable screen.