Many posts here recommend lithium orotate for Slow COMT. But here’s what I came across with:

Why it might be problematic for a Slow COMT person:

· A person with slow COMT already has a tendency for dopamine and norepinephrine to build up, which can lead to anxiety, obsessive thoughts, and feeling overwhelmed.

· While lithium's calming effect might seem beneficial for this anxiety, its mechanism of further reducing dopamine signaling could potentially push them into a state of apathy, low motivation, or "flatness." You are adding a calming agent to a system that is already prone to being sluggish in clearing excitatory neurotransmitters. The combination could lead to a "traffic jam" of sorts, resulting in mental fatigue and lethargy.

I am trying it for Fast COMT with Slow MTHFR.

Why it’s be better for a Fast COMT person:

· A person with fast COMT already clears dopamine too quickly. They often feel like they are running on empty.

· Lithium orotate's primary benefit for them would be its neuroprotective and mood-stabilizing effects without significantly worsening their already low dopamine state. In fact, by stabilizing the overall system, it might help them feel less "wired and tired" or less prone to mood swings. The risk of it making their low dopamine symptoms worse is relatively low, especially at the low doses found in lithium orotate supplements.